Research Report

Dalai Lama inspires commitment to compassion

Allison Jane Miller — Fri, 28 Feb 2025 23:36:30 +0000

Dalai Lama inspires commitment to compassion Allison Jane Miller Fri, 02/28/2025 - 16:36

Juan Niño

In March 2024, faculty, staff and students from the Renée Crown Wellness Institute, Leeds School of Business, University of Virginia and Stanford University who are affiliated with the Dalai Lama Fellows (DLF) program, traveled to Dharamsala, India. There, they spoke with His Holiness the Dalai Lama about compassionate leadership and our common humanity.

The DLF program, a one-year fellowship, supports compassionate leaders. By integrating practices of connection and contemplation into research and education, the Crown Institute provides future leaders with skills needed to address pressing global challenges.

Participants gained invaluable insights from His Holiness during the visit, enriching the collective knowledge across their organizations and communities. They returned with a commitment to bring those teachings into action across the world. The ��ɫ��Ƶ DLF program is hosted by the Crown Institute and offered to Leeds students.

Professor and Director of the Crown Institute Sona Dimidjian led two days of conversation with His Holiness the Dalai Lama.

Principals
Sona Dimidjian; Donna Mejia; Shubham Sapkota; Leah Peña Teeters

Funding
Jeremy May (Leeds School of Business, Accounting ’92); anonymous donor

Collaboration + support
CU Boulder Leeds School of Business, Renée Crown Wellness Institute; Contemplative Sciences Center at the University of Virginia; Stanford University

Learn more about this topic:
Compassion in action: Leading with heart

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Safe2Tell continues to make an impact 20 years on

Allison Jane Miller — Fri, 28 Feb 2025 23:30:10 +0000

Safe2Tell continues to make an impact 20 years on Allison Jane Miller Fri, 02/28/2025 - 16:30

Óscar Contreras

Safe2Tell, Colorado’s youth-focused harm prevention resource, has seen a record-breaking number of reports in 2024. The 20-year-old program is credited with preventing numerous potential incidents and positively impacting school safety.

After the Columbine massacre in 1999, policymakers called for effective violence prevention strategies. Former director of the Center for the Study and Prevention of Violence (CSPV) at ��ɫ��Ƶ’s Institute of Behavioral Science (IBS), Del Elliott, along with former Colorado attorney general, Ken Salazar, visited Colorado communities to gather violence prevention strategies. Safe2Tell was launched in 2004, and now operates under the Colorado Attorney General Office.

Safe2Tell has received over 164,000 reports to date. Currently, CSPV’s Violence Prevention Project has helped integrate Safe2Tell beyond its historical K–12 scope at ��ɫ��Ƶ, paving the way for adoption in higher education.

Principals
Sarah Goodrum; Beverly Kingston; Del Elliott

Funding
The Colorado Trust

Collaboration + support
��ɫ��Ƶ Center for the Study and Prevention of Violence (CSPV), Institute of Behavioral Science (IBS); Susan Payne, Colorado attorney general; Ken Salazar, former Colorado attorney general

Learn more about this topic:
More people using Safe2Tell to report safety concerns

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Voters view facts as flexible when it comes to political misinformation

Allison Jane Miller — Fri, 28 Feb 2025 23:24:25 +0000

Voters view facts as flexible when it comes to political misinformation Allison Jane Miller Fri, 02/28/2025 - 16:24

Katy Hill

Many voters aren’t bothered by politicians who misrepresent facts if the statements align with their personal beliefs, recent research suggests.

A study co-authored by Ethan Poskanzer, assistant professor of strategy and entrepreneurship in the Leeds School of Business, found a disconnect between what people believe to be “factual” and what they believe to be “true.”

The study, published in July 2024 in the American Journal of Sociology, gauged voters’ reactions to false statements by politicians including former President Donald Trump, President Joe Biden and Florida Governor Ron DeSantis. It revealed that many people use moral grounds to justify false statements.

“[It] isn’t because they believe those statements per se, but they view that misinformation as supporting political goals that they believe in,” said Poskanzer.

Principal investigator
Ethan Poskanzer

Collaboration + support
Oliver Hahl (Carnegie Mellon University, Tepper School of Business); Minjae Kim (Rice University, Jones Graduate School of Business); Ezra W. Zuckerman Sivan (Massachusetts Institute of Technology, Sloan School of Management)

Learn more about this topic:
Facts ignored: The truth is flexible when falsehoods support political beliefs

“A lot of people's support for politicians who say things that aren't true isn't because they believe those statements per se, but they view that misinformation as supporting political goals that they believe in,” said Ethan Poskanzer, an assistant professor of strategy and entrepreneurship in the Leeds School of Business and co-author of the study, which will be published in the American Journal of Sociology in June.

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The sound of science

Allison Jane Miller — Fri, 28 Feb 2025 23:03:00 +0000

The sound of science Allison Jane Miller Fri, 02/28/2025 - 16:03

Kelsey Yandura

Grace Leslie’s work with ATLAS’ Brain Music Lab transforms brain activity into sound, blending art, technology and neuroscience

Grace Leslie stands in front of a crowd, a flute perched at her lips. In many ways, the ingredients of this performance are nothing extraordinary: performer, audience, instrument … other than, perhaps, the odd-looking headband Leslie wears.

When she begins, the sounds of the flute are joined by a wash of vaguely electronic tones. The result is ethereal and strange, moving between atonal and harmonious, unsettling and soothing.

What you’re hearing are the brain waves of Leslie, an assistant professor of music technology. During this performance of Vessels, a 30-minute brain-body concert, she wears a special electroencephalogram (EEG) monitoring device that measures electrical activity from her brain. These brain waves are then sonified by means of an algorithm that imprints their spectrum onto a bank of recorded samples of flute and singing.

In other words, Leslie is playing two instruments: the flute and her own brain.

Grace Leslie

This is the sort of work Leslie does in the Brain Music Lab at the ATLAS Institute, ��ɫ��Ƶ’s interdisciplinary institute for radical creativity and invention.

The Brain Music Lab is focused on the nexus between music, technology and neuroscience. “We look at people experiencing music and study their brain waves,” said Leslie. “From there, we develop new ways of working with that data and then often transform it back into the performance or a new artistic piece.”

Typically, students begin with a broad scientific concept. For example: “What would we learn if we measured the brain waves of jazz performers during an improvisational set?”

At an ordinary lab, measuring that data may be the end result. However, the Brain Music Lab takes it a step further. Once those brain waves are measured and analyzed, the question becomes: “How do we transform what we’ve learned into a new artistic expression?” The result may be a visual art piece, a composition or even a new form of electronic instrument.

The lab works on the continuum of an art-science loop.

“It’s super exciting for a student with an electrical engineering background to be able to apply the technical skills that they have to brain waves or a medical question or to a creative pursuit,” said Leslie. “I’m constantly astounded by the work that they’re doing. They surprise me every day.”

Thiago Roque—who is pursuing a triple PhD in creative technology, neuroscience and cognitive sciences—is investigating the phenomenon of neural entrainment in musical settings to better understand social interaction and empathy.

His current research is centered on hyperscanning (a procedure that records activity in two brains at the same time) during a musical performance to better understand the neurological link between performers and audience, as well as between performers themselves. He hopes this research will help inform how we understand empathy—by watching how people interact with each other in nonverbal ways.

Jessie Lausé recently earned a master’s degree in music composition and is focusing on creating experimental works using sound from “found objects” rather than traditional instruments. Elements of a piece might include pouring out a bucket of water, ripping up crisp sheets of paper or dropping floor tiles from a height of five feet. A recent piece featured Lausé peeling a butternut squash alongside a saxophone quartet.

Lausé’s work centers on accessibility.

“I really like this idea of not needing to know how to play an instrument to engage in music,” said Lausé. “I didn’t grow up thinking that I was going to be in classical music or in academia. That was never something that was an accessible thought to me growing up.”

“ATLAS is a truly, truly unique place,” said Leslie. “Experimental work is impossible without the support of others in other disciplines.”

Principal investigator
Grace Leslie

Collaboration + support
Brain Music Lab at the ATLAS Institute; College of Music

Learn more about this topic:
The Coloradan: The sound of science

Grace Leslie’s work with ATLAS’ Brain Music Lab transforms brain activity into sound, blending art, technology and neuroscience.

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Transcending traditional notions of Native American art

Allison Jane Miller — Fri, 28 Feb 2025 22:45:50 +0000

Transcending traditional notions of Native American art Allison Jane Miller Fri, 02/28/2025 - 15:45

Clint Talbott

Whether in a somber National Portrait Gallery performance or in her wry takes on Native humor, Anna Tsouhlarakis follows her heart

Anna Tsouhlarakis was a self-described “math and science nerd” in high school, even representing the United States at the International Science and Engineering Fair in her senior year. But while studying at Dartmouth College, she took classes that interested her, particularly studio art and Native American Studies.

“That’s where my heart was, and still is,” Tsouhlarakis said. Math and science nerds might not be expected to love art, but following her heart—and contravening stereotypes—was a wise choice.

In recent years, Tsouhlarakis’ art has appeared as a solo exhibition at the Museum of Contemporary Art Denver (MCA) and New York City’s Independent Art Fair, and it has appeared in Switzerland, Greece, Canada and in dozens of other U.S. venues. In 2023, she performed and exhibited her work in the National Portrait Gallery in Washington, D.C.

Just as she broadened the notion of what might interest a budding scientist, she now transcends stereotypes of what constitutes Native American art. Tsouhlarakis, now an assistant professor of art and art history at ��ɫ��Ƶ, works in sculpture, installation, video and performance and is of Navajo, Creek and Greek descent.

At the National Portrait Gallery, her work drew on those strengths and backgrounds. There, she performed “Portrait of an Indigenous Womxn [Removed],” which commemorated murdered and missing Indigenous women and girls.

Performance of Anna Tsouhlarakis’s “Portrait of an Indigenous Womxn [Removed]” (2023) at the National Portrait Gallery

In 2018, the Urban Indian Health Institute released an extensive study on missing and murdered Indigenous women. As of 2016, there were 5,712 reports of missing American Indian and Alaska Native women, but only 116 were logged into the Department of Justice database, the National Missing and Unidentified Persons System.

“It was shocking to anybody that heard about this, and specifically to Native communities,” Tsouhlarakis said. In a gallery full of images of U.S. presidents and cultural icons, she focused her attention on those who are, to society, largely unseen.

“I knew there was nobody more important that I could highlight in terms of their story,” Tsouhlarakis observed. Her work featured missing-person posters of Indigenous women. In a video recording of one performance, she carries a sculpture topped with a poster seeking information about Kaysera Stops Pretty Places, who was murdered in 2019 in Montana.

Tsouhlarakis notes that most of her art is not activist, but rather expands upon long-held expectations of Native American art. Her father is a Navajo silversmith, and she grew up going with him to art markets, shows and galleries.

“There was this expectation of Native art to always be beautiful, and for the aesthetic to be very perfect and for it to be very serious,” she observed, adding that she rebelled against those expectations.

“I want to make things that question that expectation of Native American art, and for me, humor does that as well.” That humor was evident in her 2023 exhibition titled “Indigenous Absurdities,” at MCA Denver.

Tsouhlarakis, mother to three young children, described a key moment in which Native humor seemed an obvious way to frame Native art. While at a powwow in Montana, she overheard two Crow women conversing.

“One said, ‘You never come by to see me,’ and the other responded that she didn’t know where she lived,” Tsouhlarakis told a New York writer. “Then, one said that the other didn’t ever call them, and she said: ‘Well, you don’t even have a phone.’ Then they just burst out laughing—like almost falling off the bench.”

Such everyday observations underlie textual work like “HER FRYBREAD ISN’T THAT GOOD” and “HER BRAIDS ARE ALWAYS TOO LOOSE”. Humor, Tsouhlarakis noted, is a good coping mechanism in times of hardship, which Native communities know very well.

Tsouhlarakis’ art has been recognized and supported by a host of organizations. This year, she won a Corrina Mehiel Fellowship from S.O.U.R.C.E. Studio and a Smithsonian Artist Research Fellowship, and she’s also been recognized with more than two dozen other awards and fellowships. She also has artist residencies in New Hampshire and Maine this year.

Principal
Anna Tsouhlarakis

Funding
Corrina Mehiel Fellowship from S.O.U.R.C.E. Studio; Creative Capital Foundation; Smithsonian Artist Research Fellowship

Collaboration + support
Independent Art Fair, New York; Museum of Contemporary Art Denver; National Portrait Gallery

Learn more about this topic:
Artist transcends traditional notions of Native American art

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SHE MUST BE A MATRIARCH, 2023. Detail. Fiberglass horse, paint, adhesive, resin, plaster, plastic, wood, foam, metal, IKEA remnants, leather, prophylactics, found objects. Photo courtesy of the artist.

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Remnants of ancient virus may fuel ALS in people

Allison Jane Miller — Fri, 28 Feb 2025 22:35:30 +0000

Remnants of ancient virus may fuel ALS in people Allison Jane Miller Fri, 02/28/2025 - 15:35

Lisa Marshall

Remnants of a virus that infected our primate ancestors 30-50 million years ago may be fueling amyotrophic lateral sclerosis (ALS) in people today, according to ��ɫ��Ƶ research.

Previous studies have shown that about half of the human genome is made up of bits of DNA, including proteins, left behind by ancient viruses.

The latest research found that when one such protein, PEG10, is present at high levels in nerve tissue, it changes cell behavior in ways that contribute to the fatal, neurodegenerative disease.

The researchers are now working to find a way to inhibit the rogue protein.

“It is early days still, but the hope is this could potentially lead to an entirely new class of potential therapeutics to get at the root cause of ALS,” said author Alexandra Whiteley, assistant professor of biochemistry.

Principal investigator
Alexandra Whiteley

Funding
��ɫ��Ƶ Biological Sciences Initiative; National Cancer Institute; National Institute of General Medical Sciences

Collaboration + support
ALS Association; National Institutes of Health (NIH); Venture Partners at ��ɫ��Ƶ

Learn more about this topic:
Remnants of ancient virus may fuel ALS in people

Remnants of a virus that infected our primate ancestors 30-50 million years ago may be fueling amyotrophic lateral sclerosis (ALS) in people today, according to ��ɫ��Ƶ research.

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Social distancing plus vaccines prevented 800,000 COVID deaths

Allison Jane Miller — Fri, 28 Feb 2025 22:32:17 +0000

Social distancing plus vaccines prevented 800,000 COVID deaths Allison Jane Miller Fri, 02/28/2025 - 15:32

Lisa Marshall

Masking and social distancing until a vaccine could be developed prevented roughly 800,000 COVID-19 deaths in the U.S., according to ��ɫ��Ƶ research.

The authors gathered national mortality data and data from blood samples to estimate how many people had been infected, vaccinated or died at various points from 2020 to 2024.

They found that 68% of Americans got vaccinated before being infected. Had they gotten COVID for the first time without being vaccinated, their risk of dying would have been as much as four times higher.

“Without a behavioral response, vaccines would have come too late to save lives,” the authors wrote.

They acknowledged that distancing measures came at “tremendous economic, social and human cost” and called for the U.S. to develop a more centralized system for gathering relevant data to better target behavioral guidance during future pandemics.

Principal investigator
Stephen Kissler

Collaboration + support
The Brookings Institution; University of California, Los Angeles

Learn more about this topic:
Social distancing plus vaccines prevented 800,000 COVID deaths, but at great cost

Masking and social distancing until a vaccine could be developed prevented roughly 800,000 COVID-19 deaths in the U.S., according to ��ɫ��Ƶ research.

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Early childhood health interventions have ‘big, multi-generation impacts’

Allison Jane Miller — Fri, 28 Feb 2025 22:24:39 +0000

Early childhood health interventions have ‘big, multi-generation impacts’ Allison Jane Miller Fri, 02/28/2025 - 15:24

Daniel Long

In the late ‘90s, Tania Barham, who is now an associate professor of economics at ��ɫ��Ƶ, was in Yemen working as an economist for the World Bank, which had teamed up with UNICEF to improve that country’s health, education and water.

But something was missing: evidence.

“There was little data to understand if a project was successful or not,” she recalled.

That realization persuaded Barham to go back to school, earn a PhD and research how to bring people out of poverty over the long term.

Much of Barham’s work now draws upon data from the Maternal and Child Health and Family Planning Programme in Bangladesh, which tracks key metrics. Barham’s recent research found that the program improves people’s height, cognition and test scores.

But the most important finding, says Barham, was that these effects spanned generations. The second generation benefitted as much as the first. The takeaway: even modest health program can have “big, multi-generation impacts.”

Students participate in school activities at the Sahabatpur Daspara Ananda school in Sahabatpur village, Bangladesh. Photo Credit: Dominic Chavez, World Bank

Principal investigators
Tania Barham (��ɫ��Ƶ); Brachel Champion (U.S. Air Force Academy); Gisella Kagy (University of Wisconsin–Madison); Jena Hamadani (icddr,b)

Funding
CU Population Center; Institute of Behavioral Science (IBS); International Initiative for Impact Evaluation; National Institutes of Health (NIH)

Collaboration + support
icddr,b, an international health research institute based in Dhaka, Bangladesh; University of Wisconsin–Madison; U.S. Air Force Academy

Learn more about this topic:
Early childhood health interventions have ‘big, multi-generation impacts,’ research finds

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Major funding fuels osteoarthritis treatment collaboration

Allison Jane Miller — Fri, 28 Feb 2025 22:01:49 +0000

Major funding fuels osteoarthritis treatment collaboration Allison Jane Miller Fri, 02/28/2025 - 15:01

Heather Hansen

��ɫ��Ƶ and partners secure up to $39M ARPA-H contract to develop revolutionary joint-healing solutions for millions

In a huge win for osteoarthritis sufferers and multidisciplinary collaborations, a ��ɫ��Ƶ-led team of scientists was awarded up to $39 million from the Advanced Research Projects Agency for Health (ARPA-H) to develop new therapies to treat the painful, degenerative disease affecting 32 million Americans.

The grant, part of ARPA-H’s Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO) program, will support team efforts—including University of Colorado Anschutz and Colorado State University researchers—to create minimally-invasive therapies that bring relief for a condition affecting millions of people worldwide. It is ��ɫ��Ƶ’s first award from the new agency within the U.S. Department of Health and Human Services that supports transformative health and biomedical breakthroughs.

Osteoarthritis, the third most common disability in the U.S., causes cartilage and bone damage, often leading to increased pain and decreased mobility. The only interventions currently available either treat the pain or replace the joint—all measures that are largely insufficient, invasive or costly. Project leader and principal investigator Stephanie Bryant (chemical and biological engineering, materials science and engineering, BioFrontiers Institute) and colleagues want to change that with a therapy that regenerates cartilage and bone cells.

For over 25 years, Bryant’s work has focused on developing three-dimensional gel-like biomaterials that can provide scaffolding to support new cells. She joined forces with co-PIs Karin Payne and Michael Zuscik (both CU Anschutz; School of Medicine, Orthopedics). Payne loaned her cell expertise and Zuscik his knowledge of biologics to a process that will essentially allow a joint to repair itself.

“Within five years, our goal is to develop a suite of non-invasive therapies that can end osteoarthritis,” Bryant said recently. “It could be an absolute game-changer for patients.”

Joint imaging produced by the Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO) program

Stephanie Bryant (right) in the lab.

The dream team coalesced around AB Nexus, an initiative aimed at supporting partnerships between ��ɫ��Ƶ and CU Anschutz researchers with seed funding and other resources. The project is a great example of how combining forces can amplify effect and lead to innovative solutions to the most challenging health issues facing society, said Lisa Nanstad, a research development strategist at ��ɫ��Ƶ. She and colleagues worked first with Bryant on securing AB Nexus funding in 2020 (the catalyst for a $1.5 million grant from the National Science Foundation in 2021), and more recently on the ARPA-H funding opportunity.

“This ambitious project has the potential to profoundly impact the lives of people suffering with osteoarthritis, and it is also an inspiration to researchers across the University of Colorado,” Nanstad said. “The success of this team demonstrates the value of institutional investment in seed grant funding programs like AB Nexus.”

A key part of landing the ARPA-H grant was the team’s approach to bringing their innovation to the marketplace in a practical way. Hannah Nelson, associate director of licensing (biosciences) for Venture Partners at ��ɫ��Ƶ worked with the PI team to chart a path for successful commercialization and a detailed intellectual property strategy. “ARPA-H not only wants to see transformative research, but a strong commercialization and intellectual property plan to ensure that the innovations being developed can move beyond the universities to impact patients,” she said.

Principal investigators
Stephanie Bryant; Karin Payne; Michael Zuscik

Funding
Advanced Research Projects Agency for Health (ARPA-H) Novel Innovations for Tissue Regeneration in Osteoarthritis (NITRO) program

Collaboration + support
��ɫ��Ƶ’s BioFrontiers Institute, Department of Chemical and Biological Engineering, Materials Science and Engineering Program and Venture Partners at ��ɫ��Ƶ; Colorado State University; University of Colorado Anschutz Medical Campus

Learn more about this topic:
Joints that could heal themselves? Researchers could get there in 5 years

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The race to save honeybees

Allison Jane Miller — Fri, 28 Feb 2025 20:41:31 +0000

The race to save honeybees Allison Jane Miller Fri, 02/28/2025 - 13:41

Yvaine Ye

��ɫ��Ƶ’s Samuel Ramsey tackles the Varroa mite, a parasite devastating bee colonies and endangering vital crops worldwide

In an age where environmental threats loom large, a ��ɫ��Ƶ entomologist is pioneering an effort to save one of nature’s most crucial pollinators—the honey bee.

Over the past few years, Samuel Ramsey, assistant professor of ecology and evolutionary biology at the BioFrontiers Institute, has traveled around the world, from Thailand and Bangladesh to Taiwan, to study a parasitic mite wreaking havoc on honey bee colonies worldwide.

“The parasite is a huge issue on top of all the other threats our pollinators are dealing with, like climate change and habitat loss,” Ramsey said.

The mite, Varroa destructor, is responsible for the recent sharp decline in honey bee health around the world. The small parasite uses enzymes to dissolve bees’ livers and makes them more vulnerable to other diseases, if not killing them directly. It is estimated that beekeepers in the U.S. lost more than 48% of their honey bee colonies last year, with Varroa as the main culprit.

By studying the mite, Ramsey and his team at the Boulder Bee Lab are racing to put an end to the pollinator pandemic.

Honey bees are more than just honey makers. They are among the most efficient pollinators in nature, contributing to about $18 billion worth of crops in the U.S., including apples, peaches and potatoes.

Photo Credit: Shin Arunrugstichai

“If we lose these bees, we’re going to lose a lot of food,” Ramsey said, adding that the impacts of food insecurity can be far-reaching. “When people are hungry and don’t have necessities, conflict arises, which spills over and makes the world a more difficult place to live.”

Beekeepers have been using pesticides to control the mite, but the pesticides also harm the bees and the environment.

“There are so many honey bee colonies in the U.S., and with each of them being an additional place where chemicals are being applied, it keeps us on this pesticide treadmill that we would love to get off,” Ramsey said.

In his latest effort, Ramsey is exploring if he can tweak the bees’ genes to make them immune to Varroa and reduce pesticide use. He has previously discovered that bees in Southeast Asia, where Varroa originated, are largely resistant to the mite’s attacks, partly because of the genes they carry. If scientists could transfer these genes to honey bees in other parts of the world, it might help bees develop immunity against Varroa.

The Honey Bee-nome Project took Ramsey to Thailand, Bangladesh and Taiwan this summer, where he sampled local bees’ genomes, as well as other bee parasites and diseases that are threatening bee health. The Tropilaelaps mite, for example, is a cousin of Varroa that can spread even faster across colonies. These mites, originally from Southeast Asia, have begun to spread beyond the continent. Ramsey is closely monitoring their progression to the West in a bid to find a solution before they arrive in the U.S.

Solving the honey bee crisis will need diverse perspectives, and this holds true for many other significant challenges humanity faces today, Ramsey said.

“One of the clearest things that we’ve seen in biology is that a robust ecosystem is a diverse ecosystem. I’m glad that I get to be one of the quirky human beings who gets to focus on solving the bee problem and bring the different perspectives to the table in the entomology community,” Ramsey said.

Principal investigator
Samuel Ramsey

Funding
National Geographic Wayfinder Grant; Project Apis m. research grant; U.S. Department of Agriculture (USDA)–Animal and Plant Health Inspection Service (APHIS) Cooperative Agreement

Collaboration + support
BioFrontiers Institute; Hiveflow; Manuka Doctor

Learn more about this topic:
Fight for the honeybees

In an age where environmental threats loom large, a ��ɫ��Ƶ entomologist is pioneering an effort to save one of nature’s most crucial pollinators—the honey bee.

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