Stem Cells News

November 2024

ESC and iSPC

  • In Vitro Gametogenesis: Towards Competent Oocytes,听, BioEssays
  • Microcell-Mediated Chromosome Transfer Between Non-Identical Human iPSCs,听, Molecular Therapy 鈥 Nucleic Acids
  • Blastoid: The Future of Human Development in the Laboratory,听, Cells & Development
  • Proteomic and Functional Comparison Between Human Induced and Embryonic Stem Cells,听, eLife
  • A Comprehensive Human Embryo Reference Tool Using Single-Cell RNA-Sequencing Data,听, Nature Methods
  • Proteomic and Functional Comparison Between Human Induced and Embryonic Stem Cells,听, eLife
  • A Comprehensive Human Embryo Reference Tool Using Single-Cell RNA-Sequencing Data,听, Nature Methods
  • Inhibition of Lung Tumorigenesis by Transient Reprogramming in Cancer Cells,听, Cell Death & Disease

Neural

  • Human iPSC-Derived Neural Stem Cells Displaying Radial Glia Signature Exhibit Long-Term Safety in Mice,听, Nature Communications
  • First Patient Takes Part in New Phase I Clinical Trial for Patients with Recurrent Glioblastoma,听, UCLH NHS Foundation Trust
  • Effects of Microgravity on Human iPSC-Derived Neural Organoids on the International Space Station,听, Stem Cells Translational Medicine
  • Parkinson Disease Therapy: Current Strategies and Future Research Priorities,听, Nature Reviews Neurology
  • New Vaccines Offer Hope for Brain Tumor Patients,听, German Cancer Research Center (DKFZ)
  • White Matter Aging and Its Impact on Brain Function,听, Neuron
  • Astrocytic Proteostasis in the Tale of Aging and Neurodegeneration,听, Ageing Research Reviews

Cell Therapy

  • Intracavernosal Mesenchymal Stem Cell Therapy in Ischemic Priapism: An Experimental Study,听, International Urology and Nephrology
  • Solid Tumor Immunotherapy Using NKG2D-Based Adaptor CAR T Cells,听, Cell Reports Medicine
  • Phenotypic Insights into Genetic Risk Factors for Immune-Related Adverse Events in Cancer Immunotherapy,听, Cancer Immunology Immunotherapy
  • CAR T Cells and T Cell Therapies for Cancer,听, Jama-Journal of The American Medical Association
  • Single-Stranded DNA with Internal Base Modifications Mediates Highly Efficient Knock-In in Primary Cells Using CRISPR-Cas9,听, Nucleic Acids Research
  • Resistance to Immunomodulatory Drugs in Multiple Myeloma: The Cereblon Pathway and Beyond,听, Haematologica
  • Rational Design of Advanced Gene Delivery Carriers: Macrophage Phenotype Matters,听, Advanced Materials

Organoids

  • Human Immune Organoids to Decode B Cell Response in Healthy Donors and Patients with Lymphoma,听, Nature Materials
  • The Culture and Application of Circulating Tumor Cell-Derived Organoids,听, Trends in Cell Biology
  • Advancing Cancer Research through Organoid Technology,听, Journal of Translational Medicine
  • Organoids and Organoid Extracellular Vesicles-Based Disease Treatment Strategies,听, Journal of Nanobiotechnology
  • Physiological Modeling of the Vascularized Human Lung Organoid,听, American Journal of Respiratory Cell and Molecular Biology
  • Organoid Models of Breast Cancer in Precision Medicine and Translational Research,听, Molecular Biology Reports

October 2024

ESC and iPSC

  • Transient Promoter Interactions Modulate Developmental Gene Activation,听, Molecular Cell
  • Lateral Cell Polarization Drives Organization of Epithelia in Sea Anemone Embryos and Embryonic Cell Aggregates,听, Proceedings of The National Academy of Sciences of The United States of America
  • Human In Vitro Models for Fabry Disease: New Paths for Unravelling Disease Mechanisms and Therapies,听, Journal of Translational Medicine
  • Axol Bioscience Acquires Phenocell to Advance Human Disease Models,听, Axol, Ltd. (Business Wire)
  • How Much Energy Does It Take to Make a Baby? Researchers Are Rethinking What They Know,听, Nature
  • Genome-Wide Mapping of Native Co-Localized G4s and R-Loops in Living Cells,听, eLife
  • Early Human Development and Stem Cell-Based Human Embryo Models,听, Cell Stem Cell
  • Induced Pluripotent Stem Cells Facilitate the Development and Evaluation of Cancer Vaccines,听, Cancer Research

Neural

  • Local Glycolysis Supports Injury-Induced Axonal Regeneration,听, Journal of Cell Biology
  • Researchers Close In on Understanding Possible Cause of Alzheimer鈥檚 Disease,听, Case Western Reserve University
  • Global Effort to Map the Human Brain Releases First Data,听, Allen Institute
  • Emerging Roles of Astrocytes as Immune Effectors in the Central Nervous System,听, Trends In Immunology
  • Neuronal Wiring Diagram of an Adult Brain,听, Nature
  • Leveraging Pleiotropy for the Improved Treatment of Psychiatric Disorders,听, Molecular Psychiatry
  • Glia in Tissue Engineering: From Biomaterial Tools to Transplantation,听, Acta Biomaterialia

Cell Therapy

  • Mechanical Strategies to Promote Vascularization for Tissue Engineering and Regenerative Medicine,听, Burns & Trauma
  • World-First Therapy Using Donor Cells Sends Autoimmune Diseases into Remission,听, Nature News
  • Cell Therapy for Neurological Disorders,听, Nature Medicine
  • Exosome-Based Cell Therapy for Diabetic Foot Ulcers: Present and Prospect,听, Heliyon
  • Glia in Tissue Engineering: From Biomaterial Tools to Transplantation,听, Acta Biomaterialia
  • Advances and Applications of RNA Vaccines in Tumor Treatment,听, Molecular Cancer
  • Long-Term Lineage Commitment in Hematopoietic Stem Cell Gene Therapy,听, Nature
  • Cationized Extracellular Vesicles for Gene Delivery,听, Scientific Reports

Organoid

  • Novel Human iPSC Models of Neuroinflammation in Neurodegenerative Disease and Regenerative Medicine,听, Trends In Immunology
  • Non-Invasive Label-Free Imaging Analysis Pipeline for In Situ Characterization of 3D Brain Organoids,听, Scientific Reports
  • Tuft Cells Act As Regenerative Stem Cells in the Human Intestine,听, Nature
  • Evaluating Neuroprivacy Concerns in Human Brain Organoid Research,听, Trends In Biotechnology
  • Organoid Modeling Meets Cancers of Female Reproductive Tract,听, Cell Death Discovery
  • Mini-Brain Pressure Models Compression Injuries,听, Mirage
  • Potential Use of Organoids in Regenerative Medicine,听, Tissue Engineering and Regenerative Medicine
  • Patient-Derived Organoids: A Game-Changer in Personalized Cancer Medicine,听, Stem Cell Reviews and Reports

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September 2024

ESC and iPSC

  • Lab-Grown Stem Cells Could Be a 鈥楤reakthrough鈥 for Cancer Treatment,听, NewScientist
  • Microglial Drivers of Alzheimer鈥檚 Disease Pathology: An Evolution of Diverse Participating States,听, Proteins-Structure Function and Bioinformatics
  • Directed Differentiation of Human Embryonic Stem Cells into Conjunctival Epithelial Cells,听, Experimental Cell Research
  • The Pluripotent Path to Immunotherapy,听, Experimental Hematology
  • Parkinson鈥檚 iPSC Trial,听, Nature Biotechnology
  • Stem Cells Could Save the Giant Panda,听, The Scientist
  • The Power of Human Stem Cell-Based Systems in the Study of Neurodevelopmental Disorders,听, Current Opinion In Neurobiology

Neural

  • Aggregate-Selective Removal of Pathological Tau by Clustering-Activated Degraders,听, Science
  • Deciphering the Physiopathology of Neurodevelopmental Disorders Using Brain Organoids,听, Brain
  • Neural Circuitries between the Brain and Peripheral Solid Tumors,听, Cancer Research
  • Alzheimer鈥檚 Disease Biomarkers and Their Current Use in Clinical Research and Practice,听, Molecular Psychiatry
  • Glia in Neurodegenerative Disease,听, Cold Spring Harbor Perspectives In Biology
  • The Biology of Glia,听, Cold Spring Harbor Perspectives In Biology
  • The Power of Human Stem Cell-Based Systems in the Study of Neurodevelopmental Disorders,听, Current Opinion In Neurobiology

Cell Therapy

  • NF-魏B-Activated Oncogene Inhibition Strategy for Cancer Gene Therapy,听, nan
  • Engineered T Cell Therapy for Central Nervous System Injury,听, Nature
  • The Pluripotent Path to Immunotherapy,听, Experimental Hematology
  • CAR-T Cell Therapy: Advances in Digestive System Malignant Tumors,听, Molecular Therapy Oncology
  • Therapeutic Efficacy of Intracerebral Hematopoietic Stem Cell Gene Therapy in an Alzheimer鈥檚 Disease Mouse Model,听, Nature Communications
  • Encapsulated Islet Transplantation,听, Nature Reviews Bioengineering

Organoid

  • Organoid as a Promising Tool for Primary Liver Cancer Research: A Comprehensive Review,听, Cell & Bioscience
  • Thymic Epithelial Organoids Mediate T Cell Development,听, Development
  • Neural Tube Organoids: A Novel System to Study Developmental Timing,听, Stem Cell Reviews and Reports
  • Brain Organoid Maturation and Implantation Integration Based on Electrical Signals Input,听, Journal of Advanced Research
  • The Landscape of Drug Sensitivity and Resistance in Sarcoma,听, Cell Stem Cell
  • Using Lab-Grown Organs to Test New Spider Venom Epilepsy Drugs,听, Australian Institute for Bioengineering and Nanotechnology

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August 2024

ESC and iPSC

  • Dynamic Governance: A New Era for Consent for Stem Cell Research,听, Stem Cell Reports
  • The Fork Protection Complex Promotes Parental Histone Recycling and Epigenetic Memory,听, Cell
  • Pluripotent Stem Cell-Derived Organoids: A Brief History of Curiosity-Led Discoveries,听, BioEssays
  • Induced Pluripotent Stem Cells Facilitate the Development and Evaluation of Cancer Vaccines,听, Cancer Research
  • Substrates Mimicking the Blastocyst Geometry Revert Pluripotent Stem Cell to Naivety,听, Nature Materials
  • Combinatorial Regulatory States Define Cell Fate Diversity during Embryogenesis,听, Nature Communications
  • Individual Variation in the Emergence of Anterior-to-Posterior Neural Fates from Human Pluripotent Stem Cells,听, Stem Cell Reports
  • Patient iPSC Models Reveal Glia-Intrinsic Phenotypes in Multiple Sclerosis,听, Cell Stem Cell

Neural

  • A Functional Aged Human iPSC-Cortical Neuron Model Recapitulates Alzheimer鈥檚 Disease, Senescence, and the Response to Therapeutics,听, Alzheimers & Dementia
  • Mechanisms of Autophagy鈥揕ysosome Dysfunction in Neurodegenerative Diseases,听, Nature Reviews Molecular Cell Biology
  • FDA Approves New Therapy for Glioma Patients for First Time in Decades,听, Dana-Farber Cancer Institute
  • Melatonin: A Potential Nighttime Guardian against Alzheimer鈥檚,听, Molecular Psychiatry
  • FDA Rejects Ecstasy as a Therapy: What鈥檚 Next for Psychedelics?,听, Nature
  • Neuronal Maturation and Axon Regeneration: Unfixing Circuitry to Enable Repair,听, Nature Reviews Neuroscience
  • Tools to Study Neural and Glioma Stem Cell Quiescence,听, Trends In Neurosciences
  • Inflammatory Aspects of Alzheimer鈥檚 Disease,听, Acta Neuropathologica

Cell Therapy

  • Epigenome Editing Technologies for Discovery and Medicine,听, Nature Biotechnology
  • Quantifying Allele-Specific CRISPR Editing Activity with CRISPECTOR2.0,听, Nucleic Acids Research
  • Regenerative Cell Therapy with 3D Bioprinting,听, Science
  • Advancements and Challenges in Stem Cell Transplantation for Regenerative Medicine,听, Heliyon
  • Frontiers in CAR-T Cell Therapy for Autoimmune Diseases,听, Trends In Pharmacological Sciences
  • Applications of Cell Therapy in the Treatment of Virus-Associated Cancers,听, Nature Reviews Clinical Oncology
  • Modulating Elasticity of Liposome for Enhanced Cancer Immunotherapy,听, ACS Nano

Organoid

  • Researchers Receive McKnight Award to Study the Evolution of Deadly Brain Cancer,听, UCLA Health
  • Human Brain Organoids for Understanding Substance Use Disorders,听, Drug Metabolism and Pharmacokinetics
  • Radiation Response Assessment of Organoids Derived from Patients with Pancreatic Cancer,听, Clinical and Translational Radiation Oncology
  • Optimization of Vascularized Intestinal Organoid Model,听, Advanced Healthcare Materials
  • Research Progress of Brain Organoids in the Field of Diabetes,听, Molecular Brain
  • Liver Organoids: Updates on Generation Strategies and Biomedical Applications,听, Stem Cell Research & Therapy
  • Patient-Derived Organoid Models to Decode Liver Pathophysiology,听, Trends In Endocrinology and Metabolism
  • Mini-Brains Built From Blood: 鈥淐razy Idea鈥 Could Revolutionize Alzheimer鈥檚 Treatment,听, SciTechDaily听听

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July 2024

ESC and iPSC:

  • Kidney Disease Modeling with Organoids and Organs-on-Chips听, (Annual Review of Biomedical Engineering)
  • Brain Chimeroids Reveal Individual Susceptibility to Neurotoxic Triggers,听, (Nature)
  • Breast Cancer Patient-Derived Organoids for the Investigation of Patient-Specific Tumour Evolution,听, (Cancer Cell International)
  • Unraveling Radiation-Induced Skeletal Muscle Damage: Insights from a 3D Human Skeletal Muscle Organoid Model,听, (Biochimica Et Biophysica Acta-Molecular Cell Research)
  • Utilizing Human Cerebral Organoids to Model Breast Cancer Brain Metastasis in Culture,听, (Breast Cancer Research)
  • Cancer Organoids 2.0: Modelling the Complexity of the Tumour Immune Microenvironment,听, (Nature Reviews Cancer)
  • Establishment of Advanced Tumor Organoids with Emerging Innovative Technologies,听, (Cancer Letters)
  • Isogenic Patient-Derived Organoids Reveal Early Neurodevelopmental Defects in Spinal Muscular Atrophy Initiation,听, (Cell Reports Medicine)

Neural

  • Adult-Onset Deactivation of Autophagy Leads to Loss of Synapse Homeostasis and Cognitive Impairment, with Implications for Alzheimer Disease,听, Autophagy
  • FDA Approves Eli Lilly鈥檚 Alzheimer鈥檚 Drug Kisunla,听, NBC News
  • Adenosine Signaling to Astrocytes Coordinates Brain Metabolism and Function,听, Nature
  • The Roles of Neural Stem Cells in Myelin Regeneration and Repair Therapy after Spinal Cord Injury,听, Stem Cell Research & Therapy
  • Cellular and Pathological Functions of Tau,听, Nature Reviews Molecular Cell Biology
  • Vaccine-Based Immunotherapy and Related Preclinical Models for Glioma,听, Trends in Molecular Medicine
  • The Prion-Like Effect and Prion-Like Protein Targeting Strategy in Amyotrophic Lateral Sclerosis,听, Heliyon
  • Single-Cell Multiregion Dissection of Alzheimer鈥檚 Disease,听, Nature
  • Human Microglial Cells as a Therapeutic Target in a Neurodevelopmental Disease Model,听, Stem Cell Reports
  • Nanozymes in Alzheimer鈥檚 Disease Diagnostics and Therapy,听, Biomaterials Science
  • Axonal Mitophagy in Retinal Ganglion Cells,听, Cell Communication and Signaling

Cell Therapy

  • UCalgary Research into Reindeer Antlers Could Help Unlock Secret of Human Limb Regeneration,听, University of Calgary
  • Brain Repair Mechanisms After Cell Therapy for Stroke,听, Brain
  • Gene Therapy and Gene Editing Strategies in Inherited Blood Disorders,听, Journal of Genetics and Genomics
  • In Utero Gene Therapy and its Application in Genetic Hearing Loss,听, Advanced Biology
  • Chimeric Cell Therapy Transfers Healthy Donor Mitochondria in Duchenne Muscular Dystrophy,听, Stem Cell Reviews and Reports
  • Surface Nanocoating of Bacteria as a Versatile Platform to Develop Living Therapeutics,听, Nature Protocols
  • Retraction Notices Are Getting Clearer 鈥 but Progress Is Slow,听, Nature
  • Genetically Engineered Hypoimmunogenic Cell Therapy,听, Nature Reviews Bioengineering

Organoid

  • Kidney Disease Modeling with Organoids and Organs-on-Chips,听, Annual Review of Biomedical Engineering
  • Brain Chimeroids Reveal Individual Susceptibility to Neurotoxic Triggers,听, Nature
  • Characterization, In Vitro Elderly Digestion, and Organoids Cell Uptake of Curcumin-Loaded Nanoparticles,听, Food Chemistry
  • Biofabrication Strategies for Cardiac Tissue Engineering,听, Current Opinion In Biotechnology
  • 3D Embedded Bioprinting of Large-Scale Intestine with Complex Structural Organization and Blood Capillaries,听, Biofabrication
  • Early Human Fetal Lung Atlas Reveals the Temporal Dynamics of Epithelial Cell Plasticity,听, Nature Communications
  • Synaptic Plasticity in Human Thalamocortical Assembloids,听, Cell Reports
  • Liver and Bile Duct Organoids and Tumoroids,听, Biomedicine & Pharmacotherapy

  • 3D Cellular Self-Assembly on Optical Disc-Imprinted Nanopatterns,听, Lab On A Chip

    听

June 2024

ESC and iPSC

  • Capturing Totipotency in Human Cells through Spliceosomal Repression,听, (Cell)
  • Applications, Challenges, and Prospects of Induced Pluripotent Stem Cells for Vascular Disease,听, (Molecules and Cells)
  • X-chromosome Inactivation in Human iPSCs Provides Insight into X-Regulated Gene Expression in Autosomes,听, (Genome Biology)
  • Advances and Challenges in Modeling Inherited Peripheral Neuropathies Using iPSCs,听, (Experimental & Molecular Medicine)
  • The Relationship between Nanoscale Genome Organization and Gene Expression in Mouse Embryonic Stem Cells during Pluripotency Transition,听, (Nucleic Acids Research)
  • Molecular Mechanism of BMP Signal Control by Twisted Gastrulation,听, (Nature Communications)

Neural

  • Developmental Origin of Oligodendrocytes Determines Their Function in the Adult Brain,听, (Nature Neuroscience)
  • Protein Translation Rate Determines Neocortical Neuron Fate,听, (Nature Communications)
  • The Necroptosis Cell Death Pathway Drives Neurodegeneration in Alzheimer鈥檚 Disease,听, (Acta Neuropathologica)
  • Spinal Inhibitory Neurons Degenerate before Motor Neurons and Excitatory Neurons in a Mouse Model of ALS,听, (Science Advances)
  • Multiscale Engineering of Brain Organoids for Disease Modeling,听, (Advanced Drug Delivery Reviews)
  • Myelin Plasticity in the Ventral Tegmental Area Is Required for Opioid Reward,听, (Nature)
  • Neuronal Activity-Driven O-GlcNAcylation Promotes Mitochondrial Plasticity,听, (Developmental Cell)

Cell Therapy

  • Transient Growth Factor Expression via mRNA in Lipid Nanoparticles Promotes Hepatocyte Cell Therapy in Mice,听, (Nature Communications)
  • Heterologous Survey of 130 DNA Transposons in Human Cells Highlights Their Functional Divergence and Expands the Genome Engineering Toolbox,听, (Cell)
  • Engineering Viral Vectors for Acoustically Targeted Gene Delivery,听, (Nature Communications)
  • Bioactive-Material-Programmed CAR-T Cell Living Drug for Augmented Immunotherapy against Tumors,听, (Cell Reports Physical Science)
  • Regenerative Medicine Act Passes Final Reading at Legislature,听, (Focus Taiwan)

Organoid

  • Next-Generation Modeling of Cancer Using Organoids,听, (Cold Spring Harbor Perspectives In Medicine)
  • A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development,听, (Advanced Healthcare Materials)
  • Mice Hepatic Organoids for Modeling Nonalcoholic Fatty Liver Disease and Drug Response,, (Stem Cells and Development)
  • A Microfluidic Chip-Based Automated System for Whole-Course Monitoring the Drug Responses of Organoids,听, (Analytical Chemistry)
  • A Novel Thin Plate Spline Methodology to Model Tissue Surfaces and Quantify Tumor Cell Invasion in Organ-on-Chip Models,听, (Slas Discovery)
  • First-in-Kind Protocol for Creating Miniature Artificial Brains,听, (TECH Explorist)
  • iPSC-Derived Hindbrain Organoids to Evaluate Escitalopram Oxalate Treatment Responses Targeting Neuropsychiatric Symptoms in Alzheimer鈥檚 Disease,听, (Molecular Psychiatry)
  • Human Amniotic Mesenchymal Stem Cell-Islet Organoids Enhance the Efficiency of Islet Engraftment in a Mouse Diabetes Model,听, (Life Sciences)

May 2024

ESC and IPSC听

  • Single-Cell 3D Genome Structure Reveals Distinct Human Pluripotent States听听(Genome Biology)
  • The First Two Blastomeres Contribute Unequally to the Human Embryo听听(Cell)
  • Enhancing Genome Editing in hPSCs through Dual Inhibition of DNA Damage Response and Repair Pathways听听(Nature Communications)
  • Quantitative Proteomics Reveals the Dynamic Proteome Landscape of Zebrafish Embryos during the Maternal-to-Zygotic Transition听听(iScience)
  • Scientists Are Trying to Get Cows Pregnant with Synthetic Embryos听听(MIT Technology Review)
  • Forward Programming Human Pluripotent Stem Cells into Microglia听听(Trends in Cell Biology)
  • Cabinet Approves Two Draft Bills on Regenerative Medicine听听(Overseas Community Affairs Council, Republic of China)
  • 3D Reconstruction of a Gastrulating Human Embryo听(Cell)

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Neural听

  • The Vascular Contribution of Apolipoprotein E to Alzheimer鈥檚 Disease听听(Brain)
  • The Role of Cellular Senescence in Neurodegenerative Diseases听听(Archives Of Toxicology)
  • Itaconate Protects Ferroptotic Neurons by Alkylating GPx4 Post Stroke听听(Cell Death & Differentiation)
  • Actomyosin-II Protects Axons from Degeneration Induced by Mild Mechanical Stress听听(Journal Of Cell Biology
  • Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold听听(Cold Spring Harbor Perspectives In Biology)
  • Autism Patient-Derived SHANK2BY29X Mutation Affects the Development of ALDH1A1 Negative Dopamine Neuron听听(Molecular Psychiatry)
  • New Perspective on Sustained Antidepressant Effect: Focus on Neurexins Regulating Synaptic Plasticity听听(Cell Death Discovery)
  • Origin, Identity, and Function of Terminal Schwann Cells听听(Trends In Neurosciences)

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Cell Therapy听

  • Global Effort Aims to Protect Health and Safety of Human 鈥楪uinea Pigs鈥 in Drug Trials听听(Science Insider)
  • RNA Aggregates Harness the Danger Response for Potent Cancer Immunotherapy听听(Cell)
  • Single-Cell Transcriptome Landscape and Cell Fate Decoding in Human Brain听听Organoids after Transplantation听听(Advanced Science)
  • Promoting Alzheimer鈥檚 Disease Research and Therapy with Stem Cell Technology听听(Stem Cell Research & Therapy)
  • Mechanism of Action, Potency and Efficacy: Considerations for Cell Therapies听听(Journal Of Translational Medicine)
  • Recent Trends in 3D Bioprinting Technology for Skeletal Muscle Regeneration听听(Acta Biomaterialia)
  • GLUT1 Overexpression Enhances CAR T Cell Metabolic Fitness and Anti-Tumor Efficacy听听(Molecular Therapy)
  • First Fetus-to-Fetus Transplant Demonstrated in Rats听(Nature News)

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Organoid听

  • Pannexin1 Channel-Mediated Inflammation in Acute Ischemic Stroke听听(Aging and Disease)
  • FinalSpark Launches the First Remote Research Platform Using Human Neurons for Biocomputing听听(FinalSpark (Businesswire))
  • Establishment of Human Hematopoietic Organoids for Evaluation of Hematopoietic Injury and Regeneration Effect听听(Stem Cell Research & Therapy)
  • First Model of the Brain鈥檚 Information Highways Developed听听(Informationsdienst Wissenschaft)听
  • Cerebral Organoids Display Dynamic Clonal Growth and Tunable Tissue Replenishment听听(Nature Cell Biology)
  • High-Fat Diet Enhances Cell Proliferation and Compromises Intestinal Permeability in a Translational Canine Intestinal Organoid Model听听(BMC Molecular And Cell Biology)
  • Sebaceous Gland Organoid Engineering听听(Burns & Trauma)
  • Induced Pluripotent Stem Cells (iPSCs): Molecular Mechanisms of Induction and Applications听听(Signal Transduction And Targeted Therapy)

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April 2024

ESC and IPSC听

  • A High Efficiency Precision Genome Editing Method with CRISPR in iPSCs听听(Scientific Reports)
  • Development and Application of Haploid Embryonic Stem Cells听听(Stem Cell Research & Therapy)
  • Human Embryonic Genetic Mosaicism and Its Effects on Development and Disease听听(Nature Genetics)
  • Annelid Adult Cell Type Diversity and Their Pluripotent Cellular Origins听听(Nature Communications)
  • Reconstructing Axial Progenitor Field Dynamics in Mouse Stem Cell-Derived Embryoids听听(Developmental Cell)
  • Crispr-Based Editing of Human Pluripotent Stem Cells for Disease Modeling听听(Stem Cell Reviews and Reports)
  • Induced Pluripotent Stem Cells in Cartilage Tissue Engineering: A Literature Review听听(Bioscience Reports)
  • Scientists Made a Six-Legged Mouse Embryo 鈥 Here鈥檚 Why听听(Nature)

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Neural听

  • Origin, Identity, and Function of Terminal Schwann Cells听听(Trends In Neurosciences)
  • New Research Suggests Cerebellum May Play Important Role in Autism听 听(UC Davis Health)
  • Neural Tracing Protein-Functionalized Nanoparticles Capable of Fast Retrograde Axonal Transport in Live Neurons听听(Small)
  • An Improved Method for Generating Human Spinal Cord Neural Stem Cells听听(Experimental Neurology)
  • Neurofilaments as Biomarkers in Neurological Disorders 鈥 towards Clinical Application听听(Nature Reviews Neurology)
  • Autophagy and Exosomes; Inter-Connected Maestros in Alzheimer鈥檚 Disease听听(Inflammopharmacology)
  • Immunological Aspects of Central Neurodegeneration听(Cell Discovery)
  • The Endotoxin Hypothesis of Alzheimer鈥檚 Disease听(Molecular Neurodegeneration)

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Cell Therapy听

  • First Fetus-to-Fetus Transplant Demonstrated in Rats听(Nature News)
  • Cell Culture on Suspended Fiber for Tissue Regeneration: A Review听听(International Journal Of Biological Macromolecules)
  • Expression and Processing of Mature Human Frataxin after Gene Therapy in Mice听听(Scientific Reports)
  • This Startup Wants To Be OpenAI Of Stem Cell Therapy, Targets $250B Market听听(Forbes)
  • Mitochondrial DNA as a Target for Analyzing the Biodistribution of Cell Therapy Products听听(Scientific Reports)
  • The Dual Role of Mesenchymal Stem Cells in Apoptosis Regulation听听(Cell Death & Disease)
  • Xcell Biosciences Strengthens Cell and Gene Therapy Collaboration with Labcorp听听(Xcell Biosciences, Inc. (BusinessWire))

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Organoid听

  • Replacing Animal Testing With Stem Cell-Organoids: Advantages and Limitations听听(Stem Cell Reviews And Reports)
  • Antisense Oligonucleotide Therapeutic Approach for Timothy Syndrome听听(Nature)
  • Generation of Human Cerebral Organoids with a Structured Outer Subventricular Zone听听(Cell Reports)
  • Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction听听(Biomaterials Research)
  • Uncharted Territory: Ethical Questions Cloud Fetal Brain Organoid Research听听(Brain Tomorrow)
  • Promising Preclinical Models for Lung Cancer Research鈥擫ung Cancer Organoids: A Narrative Review听听(Translational Lung Cancer Research)
  • Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons听听(Nature Communications)
  • Generation of Human Cerebral Organoids with a Structured Outer Subventricular Zone听听(Cell Reports)

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March 2024

ESC and IPSC听

  • Diverting the Food-Freezing Technology Improves the Cryopreservation Efficiency of Induced Pluripotent Stem Cells and Derived Neurospheres听听(Regenerative Therapy)
  • Stem Cell Models of Inherited Arrhythmias听听(Nature Cardiovascular Research)
  • iPSC-Derived Models for Anorexia Nervosa Research听(Trends in Molecular Medicine)
  • Fetal Tissue Research Gains in Importance as Roadblocks Multiply听听(STAT News)
  • Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency听听(International Journal Of Stem Cells)
  • Will These Reprogrammed Elephant Cells Ever Make a Mammoth?听听(Nature)
  • Embryonic Stem Cell Transplant Showing Safety in 12 Patients听听(Parkinson鈥檚 News Today)

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Neural听

  • Biofilm Exopolysaccharides Alter Sensory-Neuron-Mediated Sickness during Lung Infection听听(Cell)
  • The Dynamics of Notch Signaling in the Neuron-Glia Switch: A Balancing Act听听(Journal Of Neurophysiology)
  • Genetically Engineered Marmosets Promise Insight into Early Stages of Parkinson鈥檚听听(Science)
  • Contrasting Somatic Mutation Patterns in Aging Human Neurons and Oligodendrocytes听听(Cell)
  • Updates on Mouse Models of Alzheimer鈥檚 Disease听(Molecular Neurodegeneration)
  • Neuropathogenesis-on-Chips for Neurodegenerative Diseases听听(Nature Communications)
  • U of T Startup Targets Harmful Side Effect of Cancer Treatment听听(University of Toronto)
  • Computer scientist Wins NSF CAREER Award to Advance Alzheimer鈥檚 Research Using AI听听(Wake Forest University)
  • Neuronal Dynamics Direct Cerebrospinal Fluid Perfusion and Brain Clearance听听(Nature)

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Cell Therapy听

  • Nanomaterials Boost CAR-T Therapy for Solid Tumors听(Advanced Healthcare Materials)
  • A Humanized Mouse Model for Adeno-Associated Viral Gene Therapy听听(Nature Communications)
  • Why Is The FDA Concerned About Secondary Cancers After CAR T Cells?听听(Forbes)
  • Synthetic Receptor Scaffolds Significantly Affect the Efficiency of Cell Fate Signals听听(Scientific Reports)
  • Targeted Nonviral Delivery of Genome Editors In Vivo听(Proceedings Of The National Academy Of Sciences Of The United States Of America)
  • Emerging Strategies for Nanomedicine in Autoimmunity听听(Advanced Drug Delivery Reviews)
  • Scripps Research Scientists Honored With Prestigious CZI Awards to Address Diseases Tied to Aging听听(Scripps Research)

听

Organoid听

  • Past and Future of Alveolar Organoids for Lung Regenerative Medicine听听(Stem Cells)
  • Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine听听(Stem Cell Reviews And Reports)
  • Establishment of Patient-Derived Organoids for Guiding Personalized Therapies in Breast Cancer Patients听听(International Journal Of Cancer)
  • Organ-on-Chip Models for Infectious Disease Research听听(Nature Microbiology)
  • Cholangiocyte Organoids to Study Drug-Induced Injury听(BMC)
  • Bioengineering Toolkits for Potentiating Organoid Therapeutics听听(Advanced Drug Delivery Reviews)
  • Cellular Reprogramming as a Tool to Model Human Aging in a Dish听听(Nature Communications)
  • Vascularized Organoid-on-a-Chip: Design, Imaging, and Analysis听听(Angiogenesis)

听

February 2024

ESC and IPSC听

  • Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons听听(Journal Of Proteome Research)
  • Cellular Reprogramming as a Tool to Model Human Aging in a Dish听 听(Nature Communications)
  • Epigenetic Reprogramming in the Transition from Pluripotency to Totipotency听听(Journal of Cell Physiology)
  • A Single-Cell Time-Lapse of Mouse Prenatal Development From Gastrula to Birth听听(Nature)
  • Pluripotent Stem Cell-Based Cardiac Regenerative Therapy for Heart Failure听听(Journal Of Molecular And Cellular Cardiology)
  • China Conducts First Nationwide Review of Retractions and Research Misconduct听听(Nature News)
  • Induced-Pluripotent Stem Cells and Neuroproteomics as Tools for Studying Neurodegeneration听听(Academic Radiology)
  • Improving Stem Cell Research听听(Harvard University)

听

Neural听

  • Multisensory Gamma Stimulation Promotes Glymphatic Clearance of Amyloid听听(Nature)
  • Neuralink Brain Chip: Advance Sparks Safety and Secrecy Concerns听听(Nature)
  • GFAP-Isoforms in the Nervous System: Understanding the Need for Diversity听听(Current Opinion in Cell Biology)
  • Dissecting the Spatiotemporal Diversity of Adult Neural Stem Cells听听(Molecular Systems Biology)
  • New Rabies Viral Resources for Multi-Scale Neural Circuit Mapping听听(Molecular Psychiatry)
  • Identification of Direct Connections between the Dura and the Brain听听(Nature)
  • 3D Printer Creates Brain Tissue That Acts like the Real Thing听听(Science)
  • Mitochondrial Stress: A Key Role of Neuroinflammation in Stroke听听(Journal of Neuroinflammation)

听

Cell Therapy听

  • Gene Therapy in Glioblastoma Multiforme: Can It Be a Role Changer?听听(Heliyon)
  • Inibitory CARs Fail to Protect From Immediate T Cell Cytotoxicity听听(Molecular Therapy)
  • In 鈥楳ajor Milestone,鈥 FDA Approves First Cell Therapy for Solid Tumors听听(STAT News)
  • Gene Therapy Allows a Deaf Child to Hear for the First Time听听(Nature Italy)
  • Host Brain Environmental Influences on Transplanted Medial Ganglionic Eminence Progenitors听听(Scientific Reports)
  • Naturally Occurring T Cell Mutations Enhance Engineered T Cell Therapies听听(Fractals-Complex Geometry Patterns And Scaling In Nature And Society)
  • Roles of Exosomes in Immunotherapy for Solid Cancers听听(Cell Death & Disease)

听

Organoid听

  • The Benefits of Stem Cell Biology and Tissue Engineering in Low-Earth Orbit听听(Stem Cells And Development)
  • Comparing Stem Cells, Transdifferentiation, and Brain Organoids as Tools for Psychiatric Research听听(Translational Psychiatry)
  • Advanced Lung Organoids for Respiratory System and Pulmonary Disease Modeling听听(Journal of Tissue Engineering)
  • A Growth Factor-Reduced Culture System for Colorectal Cancer Organoids听听(Cancer Letters)
  • Chromatin Remodeling in Patient-Derived Colorectal Cancer Models听听(Advanced Science)
  • Shaping the Neurovascular Unit Exploiting Human Brain Organoids听听(Molecular Neurobiology)
  • Live Organoid Cyclic Imaging听听(Advanced Science)
  • Characterizing Human Astrocyte Calcium Signaling in a Cerebral Organoid听听(Biophysical Journal)

听

January 2024

ESC &iPSC

  • Hallmarks of Stemness in Mammalian Tissues https://www.stemcellsciencenews.com/newsletter/219117/ (Cell Stem Cell)
  • FOXO1-Mediated Lipid Metabolism Maintains Mammalian Embryos in Dormancy https://www.stemcellsciencenews.com/newsletter/219186/ (Nature Cell Biology)
  • DNA Methylation Restricts Coordinated Germline and Neural Fates in Embryonic Stem Cell Differentiation https://www.stemcellsciencenews.com/newsletter/219185/ (Nature Structural & Molecular Biology)
  • XIST Directly Regulates X-Linked and Autosomal Genes in Naive Human Pluripotent Cells https://www.stemcellsciencenews.com/newsletter/219250/ (Cell)
  • Mitotic Bookmarking Redundancy by Nuclear Receptors in Pluripotent Cells https://www.stemcellsciencenews.com/newsletter/219390/ (Nature Structural & Molecular Biology)
  • ROR2 Expression Predicts Human-Induced Pluripotent Stem Cell Differentiation into Neural Stem/Progenitor Cells and GABAergic Neurons https://www.stemcellsciencenews.com/newsletter/219597/ (Scientific Reports)
  • Generation of Three Isogenic Human Induced Pluripotent Stem Cell Lines from Normal Neonate Skin Fibroblasts https://www.stemcellsciencenews.com/newsletter/219595/ (Stem Cell Research)
  • Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells https://www.stemcellsciencenews.com/newsletter/219593/ (Cell Reports)
  • Cloned Rhesus Monkey Lives to Adulthood for First Time https://www.stemcellsciencenews.com/newsletter/219801/ (Nature News)
  • Lineage Regulators TFAP2C and NR5A2 Function as Bipotency Activators in Totipotent Embryos https://www.stemcellsciencenews.com/newsletter/219996/ (Nature Structural & Molecular Biology)
  • ZFP281 Controls Transcriptional and Epigenetic Changes Promoting Mouse Pluripotent State Transitions via DNMT3 and TET1 https://www.stemcellsciencenews.com/newsletter/220028/ (Developmental Cell)
  • Telomere Dynamics in Human Pluripotent Stem Cells https://www.stemcellsciencenews.com/newsletter/220209/ (Cell Cycle)
  • The Impact of Induced Pluripotent Stem Cells in Animal Conservation https://www.stemcellsciencenews.com/newsletter/220205/ (Veterinary Research Communications)

Neural

  • SpaceX Returns Vital Life Science Research Sponsored by the ISS National Lab https://www.stemcellsciencenews.com/newsletter/219008/ (ISS National Lab)
  • Shigella Virulence Protein VirG Is a Broadly Protective Antigen and Vaccine Candidate https://www.stemcellsciencenews.com/newsletter/219023/ (NPJ Vaccines)
  • Combined Small-Molecule Treatment Accelerates Maturation of Human Pluripotent Stem Cell-Derived Neurons https://www.stemcellsciencenews.com/newsletter/219022/ (Nature Biotechnology)
  • Human Cerebellar Organoids with Functional Purkinje Cells https://www.stemcellsciencenews.com/newsletter/219114/ (Cell Stem Cell)
  • The Long-Term Effects of Heated Tobacco Product Exposure on the Central Nervous System in a Mouse Model of Prodromal Alzheimer鈥檚 Disease https://www.stemcellsciencenews.com/newsletter/219054/ (Scientific Reports)
  • 听Synaptic-Like Transmission between Neural Axons and Arteriolar Smooth Muscle Cells Drives Cerebral Neurovascular Coupling https://www.stemcellsciencenews.com/newsletter/219229/ (Nature Neuroscience)
  • Yap/Taz Activity Is Associated with Increased Expression of Phosphoglycerate Dehydrogenase That Supports Myoblast Proliferation https://www.stemcellsciencenews.com/newsletter/219228/ (Cell And Tissue Research)
  • Predicting Myosin Heavy Chain Isoform from Post-Dissection Fiber Length in Human Skeletal Muscle Fibers https://www.stemcellsciencenews.com/newsletter/219225/ (American Journal Of Physiology-Cell Physiology)
  • Microglia Enhance Post-Anesthesia Neuronal Activity by Shielding Inhibitory Synapses https://www.stemcellsciencenews.com/newsletter/219271/ (Nature Neuroscience)
  • Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations https://www.stemcellsciencenews.com/newsletter/219266/ (Tissue Engineering And Regenerative Medicine)
  • Neocortical Neurogenesis in Development and Evolution鈥擧uman-Specific Features https://www.stemcellsciencenews.com/newsletter/219377/ (Journal of Comparative Neurology)
  • Apically Localized PANX1 Impacts Neuroepithelial Expansion in Human Cerebral Organoids https://www.stemcellsciencenews.com/newsletter/219468/ (Cell Death Discovery)
  • First Brain Organoids Grown from Fetal Tissue Offer Window on Development https://www.stemcellsciencenews.com/newsletter/219523/ (Science)
  • Molecular Profiling of Human Substantia Nigra Identifies Diverse Neuron Types Associated with Vulnerability in Parkinson鈥檚 Disease https://www.stemcellsciencenews.com/newsletter/219671/ (Science Advances)
  • IFITM3 Promotes Glioblastoma Stem Cell-Mediated Angiogenesis via Regulating JAK/STAT3/bFGF Signaling Pathway https://www.stemcellsciencenews.com/newsletter/219772/ (Cell Death & Disease)
  • Neural Stem Cell Homeostasis Is Affected in Cortical Organoids Carrying a Mutation in Angiogenin https://www.stemcellsciencenews.com/newsletter/219773/ (Journal Of Pathology)
  • The Role of IL-6 in Neurodegenerative Disorders https://www.stemcellsciencenews.com/newsletter/219840/ (Neurochemical Research)
  • TREM2 Variants That Cause Early Dementia and Increase Alzheimer鈥檚 Disease Risk Affect Gene Splicing https://www.stemcellsciencenews.com/newsletter/219838/ (Brain)
  • DNA Methylation-Mediated Repression of microRNA-410 Promotes the Growth of Human Glioma Cells and Triggers Cell Apoptosis Through Its Interaction with STAT3 https://www.stemcellsciencenews.com/newsletter/219919/ (Scientific Reports)
  • SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence https://www.stemcellsciencenews.com/newsletter/220096/ (Cell Stem Cell)
  • Modeling the Neuroimmune System in Alzheimer鈥檚 and Parkinson鈥檚 Diseases https://www.stemcellsciencenews.com/newsletter/220168/ (Journal of Neuroinflammation)

Organoid

  • Vascularized Liver-on-a-Chip Model to Investigate Nicotine-Induced Dysfunction https://www.stemcellsciencenews.com/newsletter/219017/ (Biomicrofluidics)
  • Human Apical-Out Nasal Organoids Reveal an Essential Role of Matrix Metalloproteinases in Airway Epithelial Differentiation https://www.stemcellsciencenews.com/newsletter/219027/ (Nature Communications)
  • High-Throughput Deconvolution of 3D Organoid Dynamics at Cellular Resolution for Cancer Pharmacology with Cellos https://www.stemcellsciencenews.com/newsletter/219116/ (Nature Communications)
  • Analysis of Off-Tumor Toxicities of T Cell-Engaging Bispecific Antibodies via Donor-Matched Intestinal Organoids and Tumoroids https://www.stemcellsciencenews.com/newsletter/219115/ (Nature Biomedical Engineering)
  • Kidney Organoid Models Reveal Cilium-Autophagy Metabolic Axis as a Therapeutic Target for PKD Both In Vitro and In Vivo https://www.stemcellsciencenews.com/newsletter/219113/ (Cell Stem Cell)
  • Spatiotemporal Modulation of Growth Factors Directs the Generation of Multilineage Mouse Embryonic Stem Cell-Derived Mammary Organoids https://www.stemcellsciencenews.com/newsletter/219112/ (Developmental Cell)
  • EGFR-Activated Myofibroblasts Promote Metastasis of Pancreatic Cancer https://www.stemcellsciencenews.com/newsletter/219111/ (Cancer Cell)
  • Predictive Metabolomic Signatures for Safety Assessment of Three Plastic Nanoparticles Using Intestinal Organoids https://www.stemcellsciencenews.com/newsletter/219187/ (Science Of The Total Environment)
  • Human Fetal Brain Self-Organizes Into Long-Term Expanding Organoids https://www.stemcellsciencenews.com/newsletter/219253/ (Cell)
  • Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations https://www.stemcellsciencenews.com/newsletter/219266/ (Tissue Engineering And Regenerative Medicine)
  • A Disulfidptosis-Related lncRNAs Signature in Hepatocellular Carcinoma: Prognostic Prediction, Tumor Immune Microenvironment and Drug Susceptibility https://www.stemcellsciencenews.com/newsletter/219320/ (Scientific Reports)
  • Human Conjunctiva Organoids To Study Ocular Surface Homeostasis and Disease https://www.stemcellsciencenews.com/newsletter/219475/ (Cell Stem Cell)
  • Stem Cell Investigations to Improve Cancer Treatment Among Payloads Flying on Axiom Space鈥檚 Third Private Astronaut Mission https://www.stemcellsciencenews.com/newsletter/219474/ (ISS National Laboratory)
  • Organoids Derived From Patients Provide a New Opportunity for Research and Individualized Treatment of Malignant Peritoneal Mesothelioma https://www.stemcellsciencenews.com/newsletter/219471/ (Molecular Cancer)
  • In Vitro Models for Investigating Intestinal Host-Pathogen Interactions https://www.stemcellsciencenews.com/newsletter/219472/ (Advanced Science)
  • Uniform Cerebral Organoid Culture on a Pillar Plate by Simple and Reproducible Spheroid Transfer From an Ultralow Attachment Well Plate https://www.stemcellsciencenews.com/newsletter/219470/ (Biofabrication)
  • Precancerous Nature of Intestinal Metaplasia With Increased Chance of Conversion and Accelerated DNA Methylation https://www.stemcellsciencenews.com/newsletter/219469/ (Gut)
  • Micro instrumentation for Brain Organoids https://www.stemcellsciencenews.com/newsletter/219647/ (Advanced Healthcare Materials)
  • Bioassembly of Multicellular Spheroids to Mimic Complex Tissue Structure Using Surface-Modified Magnetized Nanofibers https://www.stemcellsciencenews.com/newsletter/219689/ (Biofabrication)
  • Gelatin-Based Hybrid Hydrogels as Matrices for Organoid Culture https://www.stemcellsciencenews.com/newsletter/219889/ (Biomacromolecules)
  • Establishment of Tumor Microenvironment-Preserving Organoid Model from Patients with Intracranial Meningioma https://www.stemcellsciencenews.com/newsletter/220164/ (Cancer Cell International)

听

December 2023

Neural News

  • The Neurobiology of SARS-CoV-2 Infection听(Nature Reviews Neuroscience)
  • Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient Treatments听(EMBO Molecular Medicine)
  • Targeting Synapse Function and Loss for Treatment of Neurodegenerative Diseases听(Nature Reviews Drug Discovery)
  • White Matter Injury across Neurodegenerative Disease听(Trends In Neurosciences)
  • Human-Specific Features and Developmental Dynamics of the Brain N-glycome听(Science Advances)
  • Efficient Generation of Brain Organoids Using Magnetized Gold Nanoparticles听(Scientific Reports)
  • Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon 伪/尾 Receptor Knockout Mice听(Neurochemical Research)
  • Econazole Selectively Induces Cell Death in NF1-Homozygous Mutant Tumor Cells听(Cell Reports Medicine)

Organoid News

  • Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient Treatments听(EMBO Molecular Medicine)
  • A Rapid and Stable Spontaneous Reprogramming System of Spermatogonial Stem Cells to Pluripotent State听(Cell & Bioscience)
  • Efficient Generation of Brain Organoids Using Magnetized Gold Nanoparticles听(Scientific Reports)
  • Applications of Lung Cancer Organoids in Precision Medicine: From Bench to Bedside听(Cell Communication and Signaling)
  • The Impact of Extracellular Matrix on the Precision Medicine Utility of Pancreatic Cancer Patient-Derived Organoids听(JCI Insight)
  • In Vitro Modeling of the Human Dopaminergic System Using Spatially Arranged Ventral Midbrain鈥揝triatum鈥揅ortex Assembloids听(Nature Methods)
  • Single-Organoid Analysis Reveals Clinically Relevant Treatment-Resistant and Invasive Subclones in Pancreatic Cancer听(NPJ Precision Oncology)
  • 3D Hepatic Organoid Production from Human Pluripotent Stem Cells听(Differentiation)
  • Single-Cell Transcriptome Profiling of Primary Tumors and Paired Organoids of Pancreatobiliary Cancer听(Cancer Letters)
  • Adult Dental Epithelial Stem Cell-Derived Organoids Deposit Hydroxylapatite Biomineral听(International Journal of Oral Science)
  • Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid Fitness听(Biofabrication)

听

ESC & iPSC

  • The Circadian Regulator PER1 Promotes Cell Reprogramming by Inhibiting Inflammatory Signaling From Macrophages听(PLOS Biology)
  • NAT10-Mediated ac4C Modification Promotes Ectoderm Differentiation of Human Embryonic Stem Cells via Acetylating NR2F1 mRNA听(Cell Proliferation)
  • Hypoblast From Human Pluripotent Stem Cells Regulates Epiblast Development听(Nature)
  • Synthetic Genetic Circuits To Uncover the OCT4 Trajectories of Successful Reprogramming of Human Fibroblasts听(Science Advances)
  • A Human Embryonic Limb Cell Atlas Resolved in Space and Time听(Nature)
  • Loss of Cohesin Regulator PDS5A Reveals Repressive Role of Polycomb Loops听(Nature Communications)
  • Evaluating the In Vitro Developmental Toxicity Potency of a Series of Petroleum Substance Extracts Using New Approach Methodologies (NAMs)听(Archives Of Toxicology)
  • Applications of Plant-made Fibroblast Growth Factor for Human Pluripotent Stem Cells听(Stem Cells And Development)
  • Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCs听(Biotechnology And Bioengineering)
  • Utility of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells for Pharmacokinetic, Toxicological, and Immunological Studies听(Biochemical And Biophysical Research Communications)
  • A Patterned Human Primitive Heart Organoid Model Generated by Pluripotent Stem Cell Self-Organization听(Nature Communications)
  • In Vitro Production of Naked Mole-Rats鈥 Blastocysts From Non-Breeding Females Using In Vitro Maturation and Intracytoplasmic Sperm Injection听(Scientific Reports)

November 2023

ESC & iPSC News

  • Metabolic Plasticity Sustains the Robustness of Caenorhabditis elegans Embryogenesis (EMBO Reports) https://www.stemcellsciencenews.com/newsletter/216547/
  • The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells (Advanced Science) https://www.stemcellsciencenews.com/newsletter/216809/
  • A Novel Perfusion Bioreactor Promotes the Expansion of Pluripotent Stem Cells in a 3D-Bioprinted Tissue Chamber (Biofabrication) https://www.stemcellsciencenews.com/newsletter/216803/
  • NR5A2 Connects Zygotic Genome Activation to the First Lineage Segregation in Totipotent Embryo(Cell Research) https://www.stemcellsciencenews.com/newsletter/217008/
  • Generation of Glucocorticoid-Producing Cells Derived from Human Pluripotent Stem Cells (Cell Reports Methods) https://www.stemcellsciencenews.com/newsletter/217006/
  • Mammalian Oocytes Store Proteins for the Early Embryo on Cytoplasmic Lattices (Cell) https://www.stemcellsciencenews.com/newsletter/217003/
  • Generation, Characterization, and Differentiation of Induced Pluripotent Stem-Like Cells in the Domestic Cat (Reproduction & Development) https://www.stemcellsciencenews.com/newsletter/217088/
  • Small Molecule-Mediated Reprogramming of Xenopus Blastula Stem Cells to a Neural Crest State (Developmental Biology) https://www.stemcellsciencenews.com/newsletter/217085/
  • This Hybrid Baby Monkey Is Made of Cells from Two Embryos (Nature) https://www.stemcellsciencenews.com/newsletter/217226/
  • Single-Cell, Whole-Embryo Phenotyping of Mammalian Developmental Disorders (Nature) https://www.stemcellsciencenews.com/newsletter/217353/
  • Generation of Induced Pluripotent Stem Cell Lines IRMBi003-A and IRMBi003-B from a Healthy Donor to Model Alzheimer鈥檚 Disease (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/217745/
  • Generation of an NCS1 Gene Knockout Human Induced Pluripotent Stem Cell Line Using CRISPR/Cas9 (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/217746/
  • Use of 2D Minilungs from Human Embryonic Stem Cells to Study the Interaction of Cryptococcus neoformans with the Respiratory Tract (Microbes And Infection) https://www.stemcellsciencenews.com/newsletter/218128/
  • Functional Engineering of Human iPSC-Derived Parasympathetic Neurons Enhances Responsiveness to Gastrointestinal Hormones (FEBS Open Bio) https://www.stemcellsciencenews.com/newsletter/218127/
  • Generation of Induced Pluripotent Stem Cell Line (RCMGi012-a) From Fibroblasts of Patient With Mucopolysaccharidosis Type VI (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/218126/

Cell Therapy News

  • CAR T Cell Design-Dependent Remodeling of the Brain Tumor-Immune Microenvironment Modulates Tumor-Associated Macrophages and Anti-Glioma Activity (Cancer Research Communications) https://www.stemcellsciencenews.com/newsletter/217570/
  • Implications of High Tumor Burden on Chimeric Antigen Receptor T Cell Immunotherapy (JAMA Oncology) https://www.stemcellsciencenews.com/newsletter/217588/
  • Anti-TACI Single and Dual-Targeting CAR T Cells Overcome BCMA Antigen Loss in Multiple Myeloma (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217569/
  • CAR T Cells for Treating Autoimmune Diseases (RMD Open) https://www.stemcellsciencenews.com/newsletter/218023/
  • Cell-Based Therapy by Autologous Bone Marrow-Derived Mononuclear Cells for Bone Augmentation of Plate-Stabilized Proximal Humeral Fractures 鈥 a Multicentric, Randomized, Open Phase IIa Study (Stem Cells Translational Medicine) https://www.stemcellsciencenews.com/newsletter/218019/
  • Genetic Retargeting of E3 Ligases to Enhance CAR T Cell Therapy (Cell Chemical Biology) https://www.stemcellsciencenews.com/newsletter/218018/
  • An In Vitro Model of the Macrophage-Endothelial Interface to Characterize CAR T-cell Induced Cytokine Storm (Scientific Reports) https://www.stemcellsciencenews.com/newsletter/216840/
  • Smart Nanoparticles for Cancer Therapy (Signal Transduction and Targeted Therapy) https://www.stemcellsciencenews.com/newsletter/216992/
  • AT7867 Promotes Pancreatic Progenitor Differentiation of Human iPSCs (Stem Cell Reports) https://www.stemcellsciencenews.com/newsletter/216989/
  • Transplanting Old Organs Promotes Senescence in Young Recipients (American Journal Of Transplantation) https://www.stemcellsciencenews.com/newsletter/216988/
  • Injectable Supramolecular Hydrogels for In Situ Programming of CAR-T Cells towards Solid Tumor Immunotherapy (Advanced Materials) https://www.stemcellsciencenews.com/newsletter/217350/

Neural Cell News

  • iPS-Cell-Derived Microglia Promote Brain Organoid Maturation via Cholesterol Transfer (Nature) https://www.stemcellsciencenews.com/newsletter/216764/
  • Neuronal TIMP2 Regulates Hippocampus-Dependent Plasticity and Extracellular Matrix Complexity (Molecular Psychiatry) https://www.stemcellsciencenews.com/newsletter/216828/
  • A Purkinje Cell to Parabrachial Nucleus Pathway Enables Broad Cerebellar Influence over the Forebrain (Nature Neuroscience) https://www.stemcellsciencenews.com/newsletter/216884/
  • A Neurodegeneration Checkpoint Mediated by REST Protects against the Onset of Alzheimer鈥檚 Disease (Nature Communications) https://www.stemcellsciencenews.com/newsletter/216883/
  • A Spinal Cord Neuroprosthesis for Locomotor Deficits Due to Parkinson鈥檚 Disease (Nature Medicine) https://www.stemcellsciencenews.com/newsletter/216959/
  • Selective Plasticity of Fast and Slow Excitatory Synapses on Somatostatin Interneurons in Adult Visual Cortex (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217048/
  • Peptide-Based Approaches to Directly Target Alpha-Synuclein in Parkinson鈥檚 Disease (Molecular Neurodegeneration) https://www.stemcellsciencenews.com/newsletter/217202/
  • STING Signaling in the Brain: Molecular Threats, Signaling Activities, and Therapeutic Challenges (Neuron) https://www.stemcellsciencenews.com/newsletter/217203/
  • Chemogenetic Approaches Reveal Dual Functions of Microglia in Seizures (Brain Behavior And Immunity) https://www.stemcellsciencenews.com/newsletter/217199/
  • The Circadian Clock Time Tunes Axonal Regeneration (Cell Metabolism) https://www.stemcellsciencenews.com/newsletter/217272/
  • Targeted Suppression of mTORC2 Reduces Seizures across Models of Epilepsy (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217307/
  • Knockout or Inhibition of USP30 Protects Dopaminergic Neurons in a Parkinson鈥檚 Disease Mouse Model (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217305/
  • Altered Corollary Discharge Signaling in the Auditory Cortex of a Mouse Model of Schizophrenia Predisposition (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217399/
  • Molecular Biomarkers for Vascular Cognitive Impairment and Dementia (Nature Reviews Neurology) https://www.stemcellsciencenews.com/newsletter/217469/
  • Mitigating Aberrant Cdk5 Activation Alleviates Mitochondrial Defects and Motor Neuron Disease Symptoms in Spinal Muscular Atrophy (Proceedings Of The National Academy Of Sciences Of The United States Of America) https://www.stemcellsciencenews.com/newsletter/217558/
  • Characterization of Neuromuscular Transmission and Projections of Muscle Motor Neurons in the Rat Stomach (American Journal Of Physiology-Gastrointestinal And Liver Physiology) https://www.stemcellsciencenews.com/newsletter/217662/
  • Asteroid Impact: The Potential of Astrocytes to Modulate Human Neural Networks within Organoids (Frontiers In Neuroscience) https://www.stemcellsciencenews.com/newsletter/217763/
  • Sequential Appetite Suppression by Oral and Visceral Feedback to the Brainstem (Nature) https://www.stemcellsciencenews.com/newsletter/217762/
  • Third-Generation Rabies Viral Vectors Allow Nontoxic Retrograde Targeting of Projection Neurons with Greatly Increased Efficiency (Cell Reports Methods) https://www.stemcellsciencenews.com/newsletter/218092/
  • Disruption of the Autism Gene and Chromatin Regulator KDM5A Alters Hippocampal Cell Identity (Science Advances) https://www.stemcellsciencenews.com/newsletter/218132/

Organoid Cell News

  • The Drug Efficacy Testing in 3D Cultures Platform Identifies Effective Drugs for Ovarian Cancer Patients (NPJ Precision Oncology) https://www.stemcellsciencenews.com/newsletter/216766/
  • Using Picoliter Droplet Deposition to Track Clonal Competition in Adherent and Organoid Cancer Cell Cultures (Scientific Reports) https://www.stemcellsciencenews.com/newsletter/216765/
  • Cancer-on-Chip Models for Metastasis: Importance of the Tumor Microenvironment (Trends In Biotechnology) https://www.stemcellsciencenews.com/newsletter/216829/
  • SARS-CoV-2 Infection Engenders Heterogeneous Ribonucleoprotein Interactions to Impede Translation Elongation in the Lungs (Experimental & Molecular Medicine) https://www.stemcellsciencenews.com/newsletter/216841/
  • In-Organoid Single-Cell CRISPR Screening Reveals Determinants of Hepatocyte Differentiation and Maturation (Genome Biology) https://www.stemcellsciencenews.com/newsletter/217081/
  • Potential Application of Intestinal Organoids in Intestinal Diseases (Stem Cell Reviews and Reports) https://www.stemcellsciencenews.com/newsletter/217179/
  • Ascorbate Protects Human Kidney Organoids From Damage Induced by Cell-Free Hemoglobin (Disease Models & Mechanisms) https://www.stemcellsciencenews.com/newsletter/217178/
  • Hepatitis C Virus Infects and Perturbs Liver Stem Cells (mBio) https://www.stemcellsciencenews.com/newsletter/217177/
  • Patient-Derived Organoids Identify Tailored Therapeutic Options and Determinants of Plasticity in Sarcomatoid Urothelial Bladder Cancer (npj Precision Oncology) https://www.stemcellsciencenews.com/newsletter/217175/
  • Reconstruction of Dynamic Mammary Mini Gland In Vitro for Normal Physiology and Oncogenesis (Nature Methods) https://www.stemcellsciencenews.com/newsletter/217171/
  • Human Intestinal Organoids From Cronkhite-Canada Syndrome Patients Reveal Link Between Serotonin and Proliferation (Journal Of Clinical Investigation) https://www.stemcellsciencenews.com/newsletter/217172/
  • Cochlear Organoids Reveal Transcriptional Programs of Postnatal Hair Cell Differentiation from Supporting Cells (Cell Reports) https://www.stemcellsciencenews.com/newsletter/217311/
  • Modular 3D Printed Platform for Fluidically Connected Human Brain Organoid Culture (Biofabrication) https://www.stemcellsciencenews.com/newsletter/217310/
  • Recent Advances in Lung Organoid Development and Applications in Disease Modeling (Journal Of Clinical Investigation) https://www.stemcellsciencenews.com/newsletter/217398/
  • Single-Cell Transcriptomics Stratifies Organoid Models of Metabolic Dysfunction-Associated Steatotic Liver Disease (EMBO Journal) https://www.stemcellsciencenews.com/newsletter/217395/
  • Human Intestinal Organoids: Modeling Gastrointestinal Physiology and Immunopathology 鈥 Current Applications and Limitations (European Journal Of Immunology) https://www.stemcellsciencenews.com/newsletter/217496/
  • Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid Fitness (Biofabrication) https://www.stemcellsciencenews.com/newsletter/217605/
  • Engineered Synthetic Matrices for Human Intestinal Organoid Culture And Therapeutic Delivery (Advanced Materials) https://www.stemcellsciencenews.com/newsletter/217768/
  • Deriving Early Single-Rosette Brain Organoids from Human Pluripotent Stem Cells (Stem Cell Reports) https://www.stemcellsciencenews.com/newsletter/217766/
  • NOTCH3 Signaling Controls Human Trophoblast Stem Cell Expansion and Differentiation (Development) https://www.stemcellsciencenews.com/newsletter/217797/
  • Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects (Cell) https://www.stemcellsciencenews.com/newsletter/218150/

October听2023

  • The Role of Zfp352 in the Regulation of Transient Expression of 2-Cell Specific Genes in Mouse Embryonic Stem Cells (Genes to Cells)
  • Telomeric DNA Breaks in Human Induced Pluripotent Stem Cells Trigger ATR-Mediated Arrest and Telomerase-Independent Telomere Damage Repair听听 (Journal of Molecular Cell Biology)
  • Transcriptomic Analysis of PADI4 Target Genes during Multi-Lineage Differentiation of Embryonic Stem Cells听听(Philosophical Transactions Of The Royal Society B-Biological Sciences)
  • The Efficient Generation of Functional Human Hepatocytes from Chemically Induced Pluripotent Stem Cells (Cell Proliferation)
  • Fabrication of Shape-Designable Cartilage from Human Induced Pluripotent Stem Cell-Derived Chondroprogenitors Using a Cell Self-Aggregation Technique听 (Biomedical Materials)
  • Functional Interrogation of Twenty Type 2 Diabetes-Associated Genes Using Isogenic Human Embryonic Stem Cell-Derived 尾-Like Cells (Cell Metabolism)
  • BRD9-Mediated Control of the TGF-尾/Activin/Nodal Pathway Regulates Self-Renewal and Differentiation of Human Embryonic Stem Cells and Progression of Cancer Cells (Nucleic Acids Research)
  • Investigation of Immune-Related Diseases Using Patient-Derived Induced Pluripotent Stem Cells(Inflammation and Regeneration)

Cell Therapy News

  • A Deregulated m6A Writer Complex Axis Driven by BRD4 Confers an Epitranscriptomic Vulnerability in Combined DNA Repair鈥揟argeted Therapy (Proceedings Of The National Academy Of Sciences Of The United States Of America)
  • Preclinical Development of a Chimeric Antigen Receptor T Cell Therapy Targeting FGFR4 in Rhabdomyosarcoma (Cell Reports Medicine)
  • Involving Stemness Factors to Improve CAR T-Cell-Based Cancer Immunotherapy (Medical Oncology)
  • Impact of Targeting Moiety Type and Protein Corona Formation on the Uptake of Fn14-Targeted Nanoparticles by Cancer Cells (ACS Nano)
  • Sustained Long-Term Disease Correction in a Murine Model of MPSII Following Stem Cell Gene Therapy (Molecular Therapy-Methods & Clinical Development)
  • Mind the GAP: RASA2 and RASA3 GTPase-Activating Proteins As Gatekeepers of T Cell Activation and Adhesion (Trends in Immunology)
  • Synthetic Transcription Factor Engineering for Cell and Gene Therapy (Trends In Biotechnology)
  • NKGen Biotech Announces FDA Clearance of Investigational New Drug Application for SNK01 NK Cell Therapy to Treat Alzheimer鈥檚 Disease (NKGen Biotech Inc.)

Neural News

  • Fe65-Engineered Neuronal Exosomes Encapsulating Corynoxine-B Ameliorate Cognition and Pathology of Alzheimer鈥檚 Disease (Signal Transduction and Targeted Therapy)
  • Clinical Trial Links Oncolytic Immunoactivation to Survival in Glioblastoma (Nature)
  • Crosstalk between Small-Cell Lung Cancer Cells and Astrocytes Mimics Brain Development to Promote Brain Metastasis (Nature Cell Biology)
  • A Humanized Chemogenetic System Inhibits Murine Pain-Related Behavior and Hyperactivity in Human Sensory Neurons (Science Translational Medicine)
  • Models for Evaluating Glioblastoma Invasion along White Matter Tracts (Trends in Biotechnology)
  • Subventricular Zone Cytogenesis Provides Trophic Support for Neural Repair in a Mouse Model of Stroke (Nature Communications)
  • Microglia and Complement Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington鈥檚 Disease (Nature Medicine)
  • This Is the Largest Map of the Human Brain Ever Made (Nature)
  • HMGA2 Directly Mediates Chromatin Condensation in Association with Neuronal Fate Regulation (Nature Communications)
  • Dexmedetomidine Alleviates Cognitive Impairment by Promoting Hippocampal Neurogenesis via BDNF/TrkB/CREB Signaling Pathway in Hypoxic鈥揑schemic Neonatal Rats (CNS Neuroscience & Therapeutics)

Organoid News

  • Establishment of a 96-Well Transwell System Using Primary Human Gut Organoids to Capture Multiple Quantitative Pathway Readouts (Scientific Reports)
  • Efficient Genetic Editing of Human Intestinal Organoids Using Ribonucleoprotein-Based CRISPR (Disease Models & Mechanisms)
  • Mapping Oto-Pharyngeal Development in a Human Inner Ear Organoid Model (Development) 听A Scalable Human Islet 3D-Culture Platform Maintains Cell Mass and Function Long-Term for Transplantation (American Journal Of Transplantation)
  • Tissue Morphology Influences the Temporal Program of Human Brain Organoid Development (Cell Stem Cell)
  • Characterization and AAV-Mediated CRB Gene Augmentation in Human Derived CRB1KO and CRB1KOCRB2+/- Retinal Organoids (Molecular Therapy-Methods & Clinical Development)
  • Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter Deficiency (eLife)
  • Unlocking the Potential of Organoids in Cancer Treatment and Translational Research: An Application of Cytologic Techniques (Cancer Cytopathology)
  • Induced Regeneration of Articular Cartilage: Identification of a Dormant Regeneration Program for a Non-regenerative Tissue Icon for the Forest of Biologists (Development)
  • Systematic Review: Predictive Value of Organoids in Colorectal Cancer听(Scientific Reports)

听

September 2023

  • GATA1 Deletion in Human Pluripotent Stem Cells Increases Differentiation Yield and Maturity of Neutrophils (iScience)
  • CHK1-CDC25A-CDK1 Regulate Cell Cycle Progression and Protect Genome Integrity in Early Mouse Embryos (EMBO Reports)
  • Recent Advances in Regulating the Proliferation or Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (Stem Cell Research & Therapy)
  • Comparison of miRNA Transcriptome of Exosomes in Three Categories of Somatic Cells with Derived iPSCs (Scientific Data)
  • Directed Differentiation of Human Pluripotent Stem Cells into Articular Cartilage Reveals Effects Caused by Absence of WISP3, the Gene Responsible for Progressive Pseudorheumatoid Arthropathy of Childhood听 (Cytotherapy)
  • Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells (CRISPR Journal)
  • KLF4 Facilitates Chromatin Accessibility Remodeling in Porcine Early Embryos (Science China Life Sciences)
  • DUX4 Expression in Cancer Induces a Metastable Early Embryonic Totipotent Program (Cell Reports)
  • Uncovering the Role of FOXA2 in the Development of Human Serotonin Neurons (Advanced Science)
  • Human Trials of Artificial Wombs Could Start Soon. Here鈥檚 What You Need to Know (Nature News)
  • Cardiac Involvement in Patient-Specific Induced Pluripotent Stem Cells of Myotonic Dystrophy Type 1: Unveiling the Impact of Voltage-Gated Sodium Channels (Frontiers in Physiology)
  • Deepening the Role of Excitation/Inhibition Balance in Human iPSCs-Derived Neuronal Networks Coupled to MEAs during Long-Term Development (Journal of Neural Engineering)
  • Accelerated Differentiation of Human Induced Pluripotent Stem Cells into Regionally Specific Dorsal and Ventral Spinal Neural Progenitor Cells for Application in Spinal Cord Therapeutics (Frontiers in Neuroscience)
  • Mini-TCRs: Truncated T Cell Receptors to Generate T Cells from Induced Pluripotent Stem Cells (Molecular Therapy-Methods & Clinical Development)
  • Monolayer Platform to Generate and Purify Primordial Germ-Like Cells In Vitro Provides Insights into Human Germline Specification (Nature Communications)
  • Induced Pluripotent Stem Cells: Ex Vivo Models for Human Diseases Due to Mitochondrial DNA Mutations (Journal of Biomedical Science)
  • TOBF1 Modulates Mouse Embryonic Stem Cell Fate through Regulating Alternative Splicing of Pluripotency Genes (Cell Reports)

听

August 2023

  • Manipulating and Studying Gene Function in Human Pluripotent Stem Cell Models (FEBS Letters)
  • Rat Post-Implantation Epiblast-Derived Pluripotent Stem Cells Produce Functional Germ Cells (Cell Reports Methods)
  • NAT10-Mediated N4-Acetylcytidine mRNA Modification Regulates Self-Renewal in Human Embryonic Stem Cells (Nucleic Acids Research)
  • Country-Specific Regulation and International Standardization of Cell-Based Therapeutic Products Derived from Pluripotent Stem Cells (Stem Cell Reports)
  • Female Na茂ve Human Pluripotent Stem Cells Carry X Chromosomes with Xa-Like and Xi-Like Folding Conformations (Science Advances)
  • A Fast Chemical Reprogramming System Promotes Cell Identity Transition through a Diapause-Like State (Nature Cell Biology)
  • Distinct Characteristics of Two Types of Alternative Lengthening of Telomeres in Mouse Embryonic Stem Cells (Nucleic Acids Research)
  • The MORC2 p.S87L Mutation Reduces Proliferation of Pluripotent Stem Cells Derived from a Patient with the Spinal Muscular Atrophy-Like Phenotype by Inhibiting Proliferation-Related Signaling Pathways (Journal Of Immunotherapy)
  • Utilizing Human Induced Pluripotent Stem Cells to Study Atrial Arrhythmias in the Short QT Syndrome (Journal Of Molecular And Cellular Cardiology)
  • Reprogramming iPSCs to Study Age-Related Diseases: Models, Therapeutics, and Clinical Trials (Mechanisms Of Ageing And Development)
  • Cell-Type-Specific Regulation of APOE and CLU Levels in Human Neurons by the Alzheimer鈥檚 Disease Risk Gene SORL1 (Cell Reports)
  • Enhancing Viability of Human Embryonic Stem Cells during Cryopreservation via RGD-REP-Mediated Activation of FAK/AKT/FoxO3a Signaling Pathway (Tissue Engineering And Regenerative Medicine)
  • Control of Stem Cell Renewal and Fate by YAP and TAZ (Nature Reviews Molecular Cell Biology)
  • Haspin Balances the Ratio of Asymmetric Cell Division Through Wnt5a and Regulates Cell Fate Decisions in Mouse Embryonic Stem Cells (Cell Death Discovery)
  • Effects of Low Doses of Methylmercury (MeHg) Exposure on Definitive Endoderm Cell Differentiation in Human Embryonic Stem Cells (Archives Of Toxicology)
  • Improved Cryopreservation of Human Induced Pluripotent Stem Cell (iPSC) and iPSC Derived Neurons Using Ice-Recrystallization Inhibitors (Stem Cells)
  • Wnt and BMP Signaling Direct Anterior/Posterior Differentiation in Aggregates of Mouse Embryonic Stem Cells (Biology Open)
  • The Induction of Parathyroid Cell Differentiation from Human Induced Pluripotent Stem Cells Promoted via TGF-伪/EGFR Signaling (Stem Cells And Development)
  • Single-Molecule Tracking of Nanog and Oct4 in Living Mouse Embryonic Stem Cells Uncovers a Feedback Mechanism of Pluripotency Maintenance (EMBO Journal)

听

July 2023

  • Building Human Artery and Vein Endothelial Cells from Pluripotent Stem Cells, and Enduring Mysteries Surrounding Arteriovenous Development (Seminars in Cell & Developmental Biology)
  • Derivation and Characteristics of Induced Pluripotent Stem Cells from a Patient with Acute Myelitis (Frontiers In Cell And Developmental Biology)
  • Chemical Genomics Reveals Targetable Programs of Human Cancers Rooted in Pluripotency (Cell Chemical Biology)
  • ZMYM2 Is Essential for Methylation of Germline Genes and Active Transposons in Embryonic Development (Nucleic Acids Research)
  • Artificial Induction of Circadian Rhythm by Combining Exogenous BMAL1 Expression and Polycomb Repressive Complex 2 Inhibition in Human Induced Pluripotent Stem Cells (Cellular and Molecular Life Sciences)
  • Effective SARS-CoV-2 Replication of Monolayers of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells (Scientific Reports)
  • Human Trophoblast Stem Cell-State Acquisition from Pluripotent Stem Cells and Somatic Cells (Current Opinion in Genetics & Development)
  • Restricting Epigenetic Activity Promotes the Reprogramming of Transformed Cells to Pluripotency in a Line-Specific Manner (Cell Death Discovery)
  • Crosstalk between RNA m6A and DNA Methylation Regulates Transposable Element Chromatin Activation and Cell Fate in Human Pluripotent Stem Cells (Nature Genetics)

June 2023

  • Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts听(Nature Communications)听
  • Human Embryonic Stem Cells Exert Antitumor Effects on Prostate Cancer Cells in a Co-Culture Microenvironment听(Frontiers In Oncology)听
  • LIS1 RNA-Binding Orchestrates the Mechanosensitive Properties of Embryonic Stem Cells in AGO2-Dependent and Independent Ways听(Nature Communications)听
  • Identification and Functional Evaluation of Alternative Splice Variants of Dax1 in Mouse Embryonic Stem Cells听(Stem Cells And Development)听
  • The Circadian Clock CRY1 Regulates Pluripotent Stem Cell Identity and Somatic Cell Reprogramming听(Cell Reports)听
  • On-Chip Real-Time Impedance Monitoring of hiPSC-Derived and Artificial Basement Membrane-Supported Endothelium听(Bioactive Materials)
  • Suspension Culture Improves iPSC Expansion and Pluripotency Phenotype听(Current Stem Cell Research & Therapy)听
  • Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse Embryo听(Nature Communications)听
  • Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts听(Nature Communications)听
  • Harnessing Three-Dimensional (3D) Cell Culture Models for Pulmonary Infections: State of the Art and Future Directions听(Naunyn-Schmiedebergs Archives Of Pharmacology)听
  • Generation of an Induced Pluripotent Stem Cell Lines NSHDMUi001-A from Patients with Type 2 Diabetes听(Stem Cell Research)
  • GSK-3伪/尾 and MEK Inhibitors Assist the Microenvironment of Tumor Initiation听(Cytotechnology)
  • A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem Cells听(Nature)听
  • Self-Patterning of Human Stem Cells into Post-implantation Lineages听(Nature)听听
  • Most Advanced Synthetic Human Embryos Yet Spark Controversy听(Nature News)听
  • Sequential and Directional Insulation by Conserved CTCF Sites Underlies the Hox Timer in Stembryos听(Nature Genetics)听
  • Cell-Membrane-Coated and Cell-Penetrating Peptide-Conjugated Trimagnetic Nanoparticles for Targeted Magnetic Hyperthermia of Prostate Cancer Cells [ACS Applied Materials & Interfaces]听
  • Comparative Landscape of Genetic Dependencies in Human and Chimpanzee Stem Cells听(Cell)听
  • Overcoming the H4K20me3 Epigenetic Barrier Improves Somatic Cell Nuclear Transfer Reprogramming Efficiency in Mice听(Cell Proliferation)听
  • Reprogramming Human Female Adipose Mesenchymal Stem Cells into Primordial Germ Cell-Like Cells听(Stem Cell Reviews And Reports)听
  • An O-GlcNAc Transferase Pathogenic Variant Linked to Intellectual Disability Affects Pluripotent Stem Cell Self-Renewal听(Disease Models & Mechanisms)听
  • Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson鈥檚 Disease Patients Carrying the Heterozygous Mutations c.815G > a (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1听)Stem Cell Research)听
  • Generation of Induced Pluripotent Stem Cell Line (XWHNi002-a) from a Female with APP Gene Mutation (Stem Cell Research)听
  • Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons听(Cellular Reprogramming)听
  • Human Prostate Organoid Generation and the Identification of Prostate Development Drivers Using Inductive Rodent Tissues听(Development)听
  • A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem Cells (Nature)听
  • Self-Patterning of Human Stem Cells into Post-implantation Lineages (Nature)听

听

听

May 2023

  • Identification of an Adipose Tissue-Resident Pro-Preadipocyte Population听(Cell Reports)听
  • Optogenetic Manipulation Identifies the Roles of ERK and AKT Dynamics in Controlling Mouse Embryonic Stem Cell Exit from Pluripotency听(Developmental Cell)听
  • Human Embryo Science: Can the World鈥檚 Regulators Keep Pace?(Nature News)听
  • Esrrb Guides Naive Pluripotent Cells through the Formative Transcriptional Programme听(Nature Cell Biology)听
  • Acoel Single-Cell Atlas Reveals Expression Dynamics and Heterogeneity of Adult Pluripotent Stem Cells听(Nature Communications)听
  • Hypo immune Induced Pluripotent Stem Cells Survive Long Term in Fully Immunocompetent, Allogeneic Rhesus Macaques听
  • (Nature Biotechnology)听https://www.nature.com/articles/s41587-023-01784-x
  • Embryonic Stem Cell ERK, AKT, Plus STAT3 Response Dynamics Combinatorics Are Heterogeneous but NANOG State Independent听(Stem Cell Reports)听
  • Generation of iPSC-Derived Human Forebrain Organoids Assembling Bilateral Eye Primordia听(Nature Protocols)听
  • A CRISPR-Engineered Isogenic Model of the 22q11.2 A-B Syndromic Deletion听(Scientific Reports)听
  • Cellular Population Dynamics Shape the Route to Human Pluripotency听
  • (Nature Communications)听https://www.nature.com/articles/s41467-023-37270-w
  • The Effect of Vitamin D3 and Valproic Acid on the Maturation of Human Induced Pluripotent Stem Cell-Derived Enterocyte-Like Cells听(Stem Cells)听https://academic.oup.com/stmcls/advance-article-abstract/doi/10.1093/stmcls/sxad042/7179740?redirectedFrom=fulltext&login=false
  • RNA Stability Controlled by m6A Methylation Contributes to X-to-Autosome Dosage Compensation in Mammals听(Nature Structural & Molecular Biology)听
  • Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse Embryo听(Nature Communications)听
  • Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement听(Stem Cells Translational Medicine)听
  • Critically Short Telomeres Derepress Retrotransposons to Promote Genome Instability in Embryonic Stem Cells听(Cell Discovery)听
  • USP7 Represses Lineage Differentiation Genes in Mouse Embryonic Stem Cells by Both Catalytic and Noncatalytic Activities听(Science Advances)听
  • Extensive Programmed Centriole Elimination Unveiled in听C. elegans听Embryos听(Science Advances)听
  • Ablation of ZC3H11A Causes Early Embryonic Lethality and Dysregulation of Metabolic Processes听
  • [Proceedings Of The National Academy Of Sciences Of The United States Of America]听
  • Reprogramming of Three-Dimensional Chromatin Organization in the Early Embryo听
  • (Current Opinion In Structural Biology)听
  • Mesodermal FGF and BMP Govern the Sequential Stages of Zebrafish Thyroid Specification听(Development)听
  • Differentiation and Single-Cell RNA-Seq Analyses of Human Pluripotent-Stem-Cell-Derived Renal Organoids听(Star Protocols)听
  • The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells听(CRISPR听Journal)https://www.liebertpub.com/doi/10.1089/crispr.2023.0013
  • First Female Arab Astronaut Reaches ISS for Historic Mission to Conduct Stem Cell & Cancer Research听(The Free Press Journal)听
  • Is Space the Place for Stem Cell Manufacturing? Scientists Will Soon Test That on the ISS听(FierceBiotech)听
  • Modulation of WNT, Activin/Nodal, and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation during Human iPSC Differentiation听(Stem Cells)听
  • MutS伪 and MutS尾 as Size-Dependent Cellular Determinants for Prime Editing in Human Embryonic Stem Cells听(Molecular Therapy 鈥 Nucleic Acids)听
  • Generation of Stable Integration-Free Pig Induced Pluripotent Stem Cells under Chemically Defined Culture Condition听(Cell Proliferation)听
  • Parallel Genome-Wide CRISPR Screens to Identify State-Dependent Self-Renewal Regulators of Mouse Embryonic Stem Cells听(Stem Cells and Development)听
  • CRISPR/Cas9 Assisted Stem Cell Therapy in Parkinson鈥檚 Disease听(Biomaterials Research)听
  • The RNA Cap Methyltransferases RNMT and CMTR1 Co-Ordinate Gene Expression during Neural Differentiation听(Biochemical Society Transactions)听
  • BCL2 Is a Major Regulator of Haploidy Maintenance in Murine Embryonic Stem Cells听(Cell Proliferation)
  • Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy听(Cell Stem Cell)
  • Establishment of Bovine Trophoblast Stem Cells (Cell Report)
  • https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00450-3
  • Chemically Defined Production of Tri-Lineage Human iPSC-Derived Cardiac Spheroids听(Current Protocols)听
  • Differentiation of Stem Cell-Derived Pancreatic Progenitors into Insulin-Secreting Islet Clusters in a Multiwell-Based Static 3D Culture System听(Cell Reports Methods)听
  • A Transcriptomic Signature of X Chromosome Overdosage in Saudi Klinefelter Syndrome Induced Pluripotent Stem Cells听(Endocrine Connections)听
  • Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca2+-Homeostasis in Clinical Arrhythmia Associated with Combined Heterozygous RYR2 and SCN10A Variants听(Philosophical Transactions Of The Royal Society B-Biological Sciences)听
  • The Generation and Properties of Human Cortical Organoids as a Disease Model for Malformations of Cortical Development听(Neural Regeneration Research)听
  • Efficient and Rapid Fluorescent Protein Knock-In with Universal Donors in Mouse Embryonic Stem Cells听(Development)听
  • A Desert lncRNA HIDEN Regulates Human Endoderm Differentiation via Interacting with IMP1 and Stabilizing FZD5 mRNA听(Genome Biology)
  • Modeling Human Skeletal Development Using Human Pluripotent Stem Cells听
  • (Proceedings Of The National Academy Of Sciences Of The United States Of America)听

听

April 2023

  • A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in听HTRA1听(Inflammation and Regeneration)听
  • Development of substrates for the culture of human pluripotent stem cells听(Biomaterials Science)听
  • Albumin-Based Solution Is the Ideal Post-thawing Suspension Medium for Cord Blood Hematopoietic Stem Cells: A Stability and Proliferative Evaluation听(Transfusion)听
  • Brain p3-Alc尾 Peptide Restores Neuronal Viability Impaired by Alzheimer鈥檚 Amyloid 尾-Peptide听(EMBO Molecular Medicine)听
  • Extracellular Vesicles in Tumor Angiogenesis and Resistance to Anti-Angiogenic Therapy听(Cancer Science)听
  • Gene Editing to Prevent Ventricular Arrhythmias Associated with Cardiomyocyte Cell Therapy听(Cell Stem Cell)听
  • Hematopoietic Stem-Cell Gene Therapy Is Associated with Restored White Matter Microvascular Function in Cerebral Adrenoleukodystrophy听(Nature Communications)听
  • Interleukin-1 Receptor Antagonist: A Promising Cytokine against Human Squamous Cell Carcinomas听(Heliyon)听
  • Modelling Hyperexcitability in Human Cerebral Cortical Organoids: Oxygen/Glucose Deprivation Most Effective Stimulant听(Heliyon)听
  • Pluripotent, Germ Cell Competent Adult Stem Cells Underlie Cnidarian Regenerative Ability and Clonal Growth听(Current Biology)听
  • Rif1听Regulates Self-Renewal and Impedes Mesendodermal Differentiation of Mouse Embryonic Stem Cells听(Stem Cell Reviews and Reports)听
  • Scalable generation of sensory neurons from human pluripotent stem cells听(STEM CELL REPORTS)听
  • Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells听(STEM CELL REPORTS)听
  • Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder听(Molecular Psychiatry)听
  • A hydrogel model of the human blood-brain barrier using differentiated stem cells听(PLOS ONE)听
  • Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation听(ACS Nano)听
  • Induced pluripotent stem cell technology in bone biology听(Science Direct)听
  • Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes听(Cell Reports)听
  • Engineering Alignment Has Mixed Effects on Human Induced Pluripotent Stem Cell Differentiated Cardiomyocyte Maturation听(Tissue Engineering Part A)听
  • Secretive Derived from Hypoxia Preconditioned Mesenchymal Stem Cells Promote Cartilage Regeneration and Mitigate Joint Inflammation via Extracellular Vesicles听(Bioactive Materials)听
  • Skeletal Muscle Gene Expression Dysregulation in Long-Term Spaceflights and Aging Is Clock-Dependent听(NPJ Microgravity)听
  • Advancing Cell Therapy for Neurodegenerative Diseases听(Cell Stem Cell)听
  • A Multi-Omics Integrative Analysis Based on CRISPR Screens Re-defines the Pluripotency Regulatory Network in ESCs听(Communications Biology)听
  • Cancer Neuroscience: State of the Field, Emerging Directions听(Cell)听
  • CRISPR-Based Functional Genomics Screening in Human-Pluripotent-Stem-Cell-Derived Cell Types(Cell Genomics)听
  • DC Vaccine Enhances CAR-T Cell Antitumor Activity by Overcoming T Cell Exhaustion and Promoting T Cell Infiltration in Solid Tumors听(Clinical And Translational Oncology)听
  • Decoding the Molecular Crosstalk between Grafted Stem Cells and the Stroke-Injured Brain听(Cell Reports)听
  • Human iPSC-Derived Neural Progenitor Cells Secreting GDNF Provide Protection in Rodent Models of ALS and Retinal Degeneration听(Stem Cell Reports)听
  • MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4听(Current Medical Science)
  • Mechanisms of Resistance and Treatment of Relapse After CAR T-Cell Therapy for Large B-Cell Lymphoma and Multiple Myeloma听(Transplantation And Cellular Therapy)
  • Progress and Emerging Techniques for Biomaterial-Based Derivation of Mesenchymal Stem Cells (MSCs) from Pluripotent Stem Cells (PSCs)听(Biomaterials Research)
  • Transforming the Understanding of Brain Immunity听(Science)
  • An听In Vivo听Neuroimmune Organoid Model to Study Human Microglia Phenotypes (Cell)
  • Directing iPSC Differentiation into iTenocytes Using Combined Scleraxis Overexpression and Cyclic Loading (Journal of Orthopaedic Research)
  • Autologous Mesenchymal Stem Cells Offer a New Paradigm for Salivary Gland Regeneration(International Journal of Oral Science)
  • Hypoimmune Induced Pluripotent Stem Cells Survive Long Term in Fully Immunocompetent, Allogeneic Rhesus Macaques(Nature Biotechnology)
  • Rescue of GM3 Synthase Deficiency by Spatially Controlled, rAAV-Mediated听ST3GAL5听Delivery (JCI Insight)
  • Effects of HDAC Inhibitors on Neuroblastoma SH-SY5Y Cell Differentiation Into Mature Neurons via the Wnt Signaling Pathway (BMC Neuroscience)
  • Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy(Cell Stem Cell)
  • Differentiation of Stem Cell-Derived Pancreatic Progenitors into Insulin-Secreting Islet Clusters in a Multiwell-Based Static 3D Culture System(Cell Reports Methods)
  • A Transcriptomic Signature of X Chromosome Overdosage in Saudi Klinefelter Syndrome Induced Pluripotent Stem Cells (Endocrine connections)
  • Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca2+-Homeostasis in Clinical Arrhythmia Associated with Combined Heterozygous听RYR2听and听SCN10A听Variants (Philosophical Transactions Of The Royal Society B-Biological Sciences)
  • Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect against Abdominal Aortic Aneurysm Formation by Inhibiting NET-Induced Ferroptosis (Communications Biology)
  • Critically Short Telomeres Derepress Retrotransposons to Promote Genome Instability in Embryonic Stem Cells(Cell Discovery) https://www.nature.com/articles/s41421-023-00538-y

听

March 2023

  • Dipeptidyl peptidase 4 Promotes Survival and Stemness of Acute Myeloid Leukemia Stem Cells听(Cell Reports)听
  • Generation of Self-Organized Autonomic Ganglion Organoids from Fibroblasts听(iScience)听
  • Human Gene-Engineered Calreticulin Mutant Stem Cells Recapitulate MPN Hallmarks and Identify Targetable Vulnerabilities听(Leukemia)听
  • Melatonin-Mediated FKBP4 Downregulation Protects against Stress-Induced Neuronal Mitochondria Dysfunctions by Blocking Nuclear Translocation of GR听(Cell Death & Disease)听
  • Patient-Derived Spheroids and Patient-Derived Organoids Simulate Evolutions of Lung Cancer听(Heliyon)听
  • Psychedelics Promote Neuroplasticity through the Activation of Intracellular 5-HT2A Receptors听(Science)听
  • A Multi-Organoid Platform Identifies CIART as a Key Factor for SARS-CoV-2 Infection听(Nature Cell Biology)听
  • Apoptosis Inhibition Enhances Induced Pluripotent Stem Cell Generation during T Cell Reprogramming听(Biochemical and Biophysical Research Communications)听
  • Clinical Use of CAR T-cells in Treating Acute Lymphoblastic Leukemia听(Transfusion And Apheresis Science)听
  • Dying Transplanted Neural Stem Cells Mediate Survival Bystander Effects in the Injured Brain听(Cell Death & Disease)听
  • Fibroblast Heterogeneity: Keystone of Tissue Homeostasis and Pathology in Inflammation and Aging听(Frontiers In Immunology)听
  • Generation of Functional Oocytes from Male Mice听In Vitro听(Nature)听
  • Highly Efficient and Rapid Generation of Human Pluripotent Stem Cells by Chemical Reprogramming听(Cell Stem Cell)听
  • Improved Survival of Patients with Primary Plasma Cell Leukemia with VRd or Daratumumab-based Quadruplets: A Multicenter Study by the Greek Myeloma Study Group听(American Journal Of Hematology)
  • Implantation of Engineered Human Microvasculature to Study Human Infectious Diseases in Mouse Models听(iScience)听
  • The Novel GATA1-Interacting Protein HES6 Is an Essential Transcriptional Cofactor for Human Erythropoiesis听(Nucleic Acids Research)听
  • Very Small Embryonic-Like Stem Cells Transform into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test听(Stem Cells)

听

February 2023

  • A Molecular Characterization and Clinical Relevance of Microglia-Like Cells Derived from Patients with Panic Disorder听(Translational Psychiatry)听
  • Bioengineering Approaches to Promote Maturity in Human Skeletal Muscle Constructs听(Biophysical Journal)听
  • Cancer Stem Cells: Recent Insights and Therapies听(Biochemical Pharmacology)听
  • Supports Meso-Endoderm Differentiation from Mouse Embryonic Stem Cells听(Nature Communications)听
  • Inflammation and DNA Damage: Cause, Effect or Both听(Nature Reviews Rheumatology)听
  • iPSC-Based Modeling of THD Recapitulates Disease Phenotypes and Reveals Neuronal Malformation听(EMBO Molecular Medicine)听
  • Lnc956-TRIM28-HSP90B1 Complex on Replication Forks Promotes CMG Helicase Retention to Ensure Stem Cell Genomic Stability and Embryogenesis听(Science Advances)听
  • Multicenter Long-Term Follow-Up of Allogeneic Hematopoietic Cell Transplantation with Omidubicel: A Pooled Analysis of Five Prospective Clinical Trials听(Transplantation And Cellular Therapy)听
  • NANOGP1, a Tandem Duplicate of NANOG, Exhibits Partial Functional Conservation in Human Na茂ve Pluripotent Stem Cells听(Development)听
  • Nanosheet Coating Improves Stability of Human Pluripotent Stem Cell Culture on Glass Substrates听(Biochemical and Biophysical Research Communications)听
  • Reversal of Aging-Associated Increase in Myelopoiesis and Expression of Alarmins by Angiotensin-(1鈥7)听(Scientific Reports)听
  • Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment听(Nature Communications)听
  • Transgenic Skin Biomechanical Properties Following First Lifesaving Epidermal Regeneration Using Combined Gene and Cell Therapy听(Journal of the German Society of Dermatology)听

听

January 2023

  • Administration of Stem Cells against Cardiovascular Diseases with a Focus on Molecular Mechanisms: Current Knowledge and Prospects听(Tissue and Cell)听
  • Binary Colloidal Crystals Promote Cardiac Differentiation of Human Pluripotent Stem Cells via Nuclear Accumulation of SETDB1听(ACS Nano)听
  • Corneal Stem Cells Niche and Homeostasis Impacts in Regenerative Medicine; Concise Review听(European Journal of Ophthalmology)听
  • Cross-Species Transcriptomic Atlas of Dorsal Root Ganglia Reveals Species-Specific Programs for Sensory Function听(Nature Communications)听
  • Endothelial Cell-Derived Exosomes Boost and Maintain Repair-Related Phenotypes of Schwann Cells via miR199-5p to Promote Nerve Regeneration听(Journal Of Nanobiotechnology)听
  • Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down Syndrome听(Stem Cell Reviews and Reports)听
  • Human iPSC-Derived Preclinical Models to Identify Toxicity of Tumor-Specific T Cells with Clinical Potential听(Molecular Therapy-Methods & Clinical Development)听
  • Photoreceptor Laminin Drives Differentiation of Human Pluripotent Stem Cells to Photoreceptor Progenitors That Partially Restore Retina Function听(Molecular Therapy)听
  • Progenitor-Derived Endothelin Controls Dermal Sheath Contraction for Hair Follicle Regression听(Nature Cell Biology)听
  • Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate under BMP4 Induction from Human Pluripotent Stem Cells听(Stem Cells)听
  • The Impact of the Cellular Environment and Aging on Modeling Alzheimer鈥檚 Disease in 3D Cell Culture Models听(Advanced Science)听
  • Transcriptional and Functional Effects of Lithium in Bipolar Disorder iPSC-Derived Cortical Spheroids听(Molecular Psychiatry)听
  • Transplanted Human iPSC-Derived Vascular Endothelial Cells Promote Functional Recovery by Recruitment of Regulatory T Cells to Ischemic White Matter in the Brain听(Journal of Neuroinflammation)听

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December 2022

路听听听听听听RNA Degradation Eliminates Developmental Transcripts during Murine Embryonic Stem Cell Differentiation via CAPRIN1-XRN2听

路听听听听 听Embryonic Origins of Adult Pluripotent Stem Cells听

路听听听听听听Bulk RNA sequencing analysis of developing human induced pluripotent cell-derived retinal organoids听

路听听听听听听Effect of thymoquinone on pharmacokinetics of 5-fluorouracil in rats and its effect on human cell line听in vitro听

路听听听听听听Stress-Induced Reversible Cell-Cycle Arrest Requires PRC2/PRC1-Mediated Control of Mitophagy in听Drosophila听Germline Stem Cells and Human iPSCs听

路听听听听听 Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells听

路听听听听听听Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells听

路听听听听听听CD34dim听cells identified as pluripotent stem cell-derived definitive hemogenic endothelium purified using bone morphogenetic protein 4听

路听听听听听听A Reference Human Induced Pluripotent Stem Cell Line for Large-Scale Collaborative Studies听

路听听听听听 The Consequences of Recurrent Genetic and Epigenetic Variants in Human Pluripotent Stem Cells听

路听听听听听听Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density听

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November 2022

  • Long-Range Axonal Projections of Transplanted Mouse Embryonic Stem Cell-Derived Hypothalamic Neurons into Adult Mouse Brain听(PLoS One)听
  • Modeling Placental Development and Disease Using Human Pluripotent Stem Cells听(Placenta)
  • Transcription Factor Antagonism Regulates Heterogeneity in Embryonic Stem Cell States听(Molecular Cell)听
  • Membrane Potential Drives the Exit from Pluripotency and Cell Fate Commitment via Calcium and mTOR听(Nature Communications)听
  • Lamin A/C-dependent Chromatin Architecture Safeguards Na茂ve Pluripotency to Prevent Aberrant Cardiovascular Cell Fate and Function听(Nature Communications)听
  • Virtual Cells in a Virtual Microenvironment Recapitulate Early Development-Like Patterns in Human Pluripotent Stem Cell Colonies听(Stem Cell Reports)听
  • Stabilization of hESCs in Two Distinct Substrates along the Continuum of Pluripotency听(iScience)听
  • Acute Severe Hypoxia Induces Apoptosis of Human Pluripotent Stem Cells by a HIF-1伪 and P53 Independent Mechanism听(Scientific Reports)听
  • Intermediate Cells of听In Vitro听Cellular Reprogramming and听In Vivo听Tissue Regeneration Require Desmoplakin听(Science Advances)听
  • Transient Inhibition of p53 Enhances Prime Editing and Cytosine Base-Editing Efficiencies in Human Pluripotent Stem Cells听(Nature Communications)听
  • Stabilization of Cell-Cell Adhesions Prevents Symmetry Breaking and Locks In Pluripotency in 3D Gastruloids听(Stem Cell Reports)听
  • Nucleosome Breathing Facilitates Cooperative Binding of Pluripotency Factors Sox2 and Oct4 to DNA(Biophysical Journal)听
  • Therapeutic Function of a Novel Rat Induced Pluripotent Stem Cell Line in a 6-OHDA-Induced Rat Model of Parkinson鈥檚 Disease听(International Journal of Molecular Medicine])听
  • Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells That Are Defective in Self-Renewal听(International Journal of Stem Cells)
  • Using Pluripotent Stem Cells to Understand Normal and Leukemic Hematopoietic Development听(Stem Cells Translational Medicine)听

听

October 2022

World鈥檚 first stem cell treatment for spina bifida delivered during fetal surgery!听听 听

  • Identification of Stable Housekeeping Genes for Induced Pluripotent Stem Cells and -Derived Endothelial Cells for Drug Testing (Scientific Reports)听https://www.nature.com/articles/s41598-022-20435-w
  • TGF尾 Superfamily Signaling Regulates the State of Human Stem Cell Pluripotency and Capacity to Create Well-Structured Telencephalic Organoids (Stem Cell Reports)听https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00422-2
  • The Kleisin Subunits of Cohesin Are Involved in the Fate Determination of Embryonic Stem Cells (Molecules and Cells)听https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2022.2042听
  • Human Cellular Models for Retinal Disease: From Induced Pluripotent Stem Cells to Organoids (Retina-the Journal of Retinal and Vitreous Diseases)听https://journals.lww.com/retinajournal/Abstract/2022/10000/HUMAN_CELLULAR_MODELS_FOR_RETINAL_DISEASE__From.1.aspx听
  • Super-Enhancers Conserved within Placental Mammals Maintain Stem Cell Pluripotency (Proceedings of the National Academy of Sciences of the United States of America)听https://www.pnas.org/doi/10.1073/pnas.2204716119听
  • High Glucose Impairs Osteogenic Differentiation of Embryonic Stem Cells via Early Diversion of Beta-Catenin from Forkhead Box O to T Cell Factor Interaction (Birth Defects Research)听https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2085

听

September听2022

  • Retinoic Acid Delays Initial Photoreceptor Differentiation and Results in a Highly Structured Mature Retinal Organoid (Stem Cell Research & Therapy)听https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03146-x
  • Engineering Placenta-Like Organoids Containing Endogenous Vascular Cells from Human-Induced Pluripotent Stem Cells (Bioengineering & Translational Medicine)听https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10390听
  • Induction of Functional Xeno-Free MSCs from Human iPSCs via a Neural Crest Cell Lineage (NPJ Regenerative Medicine)听https://www.nature.com/articles/s41536-022-00241-8
  • CTCF Acetylation at Lysine 20 Is Required for the Early Cardiac Mesoderm Differentiation of Embryonic Stem Cells (Cell Regeneration)听https://cellregeneration.springeropen.com/articles/10.1186/s13619-022-00131-w
  • Evolutionary Origin of Vertebrate OCT4/POU5 Functions in Supporting Pluripotency (Nature Communications)听https://www.nature.com/articles/s41467-022-32481-z
  • Dominant Role of DNA Methylation over H3K9me3 for IAP Silencing in Endoderm (Nature Communications)听https://www.nature.com/articles/s41467-022-32978-7
  • LncRNA-Smad7 Mediates Cross-Talk between Nodal/TGF-尾 and BMP Signaling to Regulate Cell Fate Determination of Pluripotent and Multipotent Cells (Nucleic Acids Research)听https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac780/6711145
  • Passage Number Affects Differentiation of Sensory Neurons from Human Induced Pluripotent Stem Cells (Scientific Reports)听https://www.nature.com/articles/s41598-022-19018-6听
  • Modeling Urea Cycle Disorders Using iPSCs (NPJ Regenerative Medicine)听https://www.nature.com/articles/s41536-022-00252-5
  • Building听In Vitro听Models of the Brain To Understand the Role of APOE in Alzheimer鈥檚 Disease听[Life Science Alliance]听https://www.life-science-alliance.org/content/5/11/e202201542听
  • PFOS Disrupts Key Developmental Pathways during hiPSC Derived Cardiomyocyte Differentiation (In Vitro听Toxicology in Vitro)听https://www.sciencedirect.com/science/article/pii/S0887233322001734?via%3Dihub
  • Imprinting Fidelity in Mouse iPSCs Depends on Sex of Donor Cell and Medium Formulation (Nature Communications)听https://www.nature.com/articles/s41467-022-33013-55
  • CRISPR-Cas9 Screen in Human Embryonic Stem Cells to Identify Genes Required for Neural Differentiation (STAR Protocols)听https://www.sciencedirect.com/science/article/pii/S2666166722005627?via%3Dihub
  • Different Transcriptional Profiles of Human Embryonic Stem Cells Grown in a Feeder-Free Culture System and on Human Foreskin Fibroblast Feeder Layers (Aging-Us)听https://www.aging-us.com/article/204282/text
  • Fast Generation of Forebrain Oligodendrocyte Spheroids from Human Embryonic Stem Cells by Transcription Factors听(iScience)听https://www.cell.com/action/showPdf?pii=S2589-0042%2822%2901444-4
  • METTLing in Stem Cell and Cancer Biology (Stem Cell Reviews and Reports)听https://link.springer.com/article/10.1007/s12015-022-10444-7
  • A Stem Cell Roadmap of Ribosome Heterogeneity Reveals a Function for RPL10A in Mesoderm Production (Nature Communications)听https://www.nature.com/articles/s41467-022-33263-3
  • Human PSCs Determine the Competency of Cerebral Organoid Differentiation via FGF Signaling and Epigenetic Mechanisms (iScience)听https://www.cell.com/action/showPdf?pii=S2589-0042%2822%2901412-2听
  • Mouse Embryo Model Derived Exclusively from Embryonic Stem Cells Undergoes Neurulation and Heart Development (Cell Stem Cell)听https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00377-0
  • Heparinized Gelatin-Based Hydrogels for Differentiation of Induced Pluripotent Stem Cells (Biomacromolecules)听https://pubs.acs.org/doi/10.1021/acs.biomac.2c00585
  • Acquisition and Maintenance of Pluripotency Are Influenced by Fibroblast Growth Factor, Leukemia Inhibitory Factor, and 2i in Bovine-Induced Pluripotent Stem Cells听(Frontiers in Cell and Developmental Biology)听https://www.stemcellsciencenews.com/newsletter/194131/
  • Recent Advances for Using Human Induced-Pluripotent Stem Cells as Pain-in-a-Dish Models of Neuropathic Pain (Experimental Neurology)听https://www.sciencedirect.com/science/article/pii/S0014488622002485?via%3Dihub
  • Modeling Metabolic Diseases and Drug Response Using Stem Cells and Organoids (Nature Reviews Endocrinology)听https://www.nature.com/articles/s41574-022-00733-z
  • Harnessing Conserved Signaling and Metabolic Pathways to Enhance the Maturation of Functional Engineered Tissues (NPJ Regenerative Medicine)听https://www.nature.com/articles/s41536-022-00246-3
  • Spatial Molecular Anatomy of Germ Layers in the Gastrulating Cynomolgus Monkey Embryo (Cell Reports)听https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01105-6
  • Modeling Human Extraembryonic Mesoderm Cells Using Naive Pluripotent Stem Cells (Cell Stem Cell)听https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00337-X
  • Systemic Proteomics and miRNA Profile Analysis of Exosomes Derived from Human Pluripotent Stem Cells (Stem Cell Research & Therapy)听https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03142-1
  • Robust Genome Editing via modRNA-Based Cas9 or Base Editor in Human Pluripotent Stem Cells (Cell Reports Methods)听https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(22)00172-2
  • Molecular Convergence between Down Syndrome and Fragile X Syndrome Identified Using Human Pluripotent Stem Cell Models (Cell Reports)听https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01136-6
  • Modeling Human Multi-Lineage Heart Field Development with Pluripotent Stem Cells (Cell Stem Cell)听https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00343-5听
  • Generation of Human Induced Pluripotential Stem Cells from Individuals with Complex Heterozygous, Isogenic Corrected, and Homozygous听Bloc1s1听Mutations听(Stem Cell Research)听https://www.sciencedirect.com/science/article/pii/S1873506122002549

听

August 2022

  • DLL4 and VCAM1 Enhance the Emergence of T Cell鈥揅ompetent Hematopoietic Progenitors from Human Pluripotent Stem Cells (Science Advances)听https://www.science.org/doi/10.1126/sciadv.abn5522
  • Repeated Intravenous Administration of hiPSC-MSCs Enhance the Efficacy of Cell-Based Therapy in Tissue Regeneration (Communications Biology)听https://www.nature.com/articles/s42003-022-03833-8

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