We used genomic structural equation modeling to investigate the shared genetics of internalizing, externalizing, and alcohol use traits, as well as to explore whether specific domains of internalizing symptoms mediate the contrasting relationships with problematic alcohol use compared to alcohol consumption. Individual internalizing domains had contrasting effects on frequency of alcohol consumption, which demonstrate the complex system of pleiotropy that exists, even within similar disorders, and can be missed when evaluating only relationships among formal diagnoses.
(American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2024)
Gene-gene interaction associations of complex traits.
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(PLOS Genetics, 2023)
Estimating rare variant contribution to smoking traits.
(Nature Human Behavior, 2022)
Genetically dissected the relationships between internalizing disorders and alcohol use and problematic use into genome-wide, tissue- and region-specific, and pathway contributions to the genetic relationships. Provides insight into the genetic basis to the comorbidity between problematic alcohol use and internalizing disorders.
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(Neuropsychiatric Genetics, Part B, 2021)
Testing whether genes thought a prior to be implicated in smoking and addictions explain much of the variance in smoking behaviors, finding that in general they explain very little which indicates high polygenicity and multiple genetic influences.
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(Nicotine & Tobacco Research, 2021)
Evaluation of methods to estimate SNP-heritability and development of improved approach.
